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Polymyxin B as scaffold for new analogues bearing uncommon amino acids: synthes...

The alarming rise of antimicrobial resistance (AMR) and multidrug-resistant (MDR) Gram-negative bacteria led the World Health Organization (WHO) to publish a list of pathogens for which the development of new antibiotics is urgent. Some bacteria have been prioritized as they are resistant to more than three classes of antibiotics, such as the ESKAPE group that includes Gram-positive bacteria (Enterococcus faeci...