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Advanced Stage Hepatocellular Carcinoma with Multiple Metastasis and Vascular T...
Simão, Adélia; Silva, Raquel; Correia, Lurdes; Alves, Filipe Caseiro; Carvalho, Armando; Costa, J. M. NascimentoSorafenib is a multi-targeted tyrosine kinase inhibitor, with antiangiogenic and antiproliferative properties, approved for the treatment of advanced hepatocellular carcinoma. It induces a significant increase in the median overall survival, despite a complete response to treatment being rare. We report a clinical case of a 60-year-old male with hepatic cirrhosis, Child-Pugh class A and performance status 0, an...
Advanced Stage Hepatocellular Carcinoma with Multiple Metastasis and Vascular T...
Simão, Adélia; Silva, Raquel; Correia, Lurdes; Alves, Filipe Caseiro; Carvalho, Armando; Costa, J. M. NascimentoSorafenib is a multi-targeted tyrosine kinase inhibitor, with antiangiogenic and antiproliferative properties, approved for the treatment of advanced hepatocellular carcinoma. It induces a significant increase in the median overall survival, despite a complete response to treatment being rare. We report a clinical case of a 60-year-old male with hepatic cirrhosis, Child-Pugh class A and performance status 0, an...
Churg-Strauss syndrome: case series
Alfaro, T. M.; Duarte, C.; Monteiro, R.; Simão, A.; Calretas, S.; Costa, J. M. NascimentoA síndromedeChurg-Strauss(SCS)éumavasculitesistémicanecrotizante,queafeta os vasosdepequenoemédiocalibreeseassociaagranulomaseosinofílicosextravasculares, eosinofilia periféricaeasma. É umasíndromerara,deetiologiadesconhecidaequeafetaambososgénerosetodosos grupos etários. Os doentescomSCSgeralmenteapresentamboarespostaàterapêuticacomglucocorticoi- des, emboraasrecidivassejamfrequentesapósasuasuspensão.Odiagnóst...