77 documents found, page 1 of 8

Determination of parental origin of Gestational Trophoblastic Disease using MS-...

Background: Gestational trophoblastic disease (GTD) is a rare condition marked by abnormal proliferation of placental trophoblastic cells and encompasses a heterogeneous group of disorders with distinct clinical, imaging, and histological features, each requiring tailored therapeutic approaches. Although GTD generally has a good prognosis, early diagnosis, targeted treatment, and continuous surveillance are ess...

Urinary volatile metabolomic biomarkers for detection of bladder cancer

Background: Early detection of bladder cancer (BC) is necessary for improved outcomes, but current diagnostic methods may lack the necessary sensitivity. Metabolomics, particularly the analysis of urinary volatile organic compounds (VOCs), offers a promising, non-invasive approach to BC detection [1,2]. Objective: The study aimed to investigate potential urinary biomarkers for the detection and staging of ...

Metabolic profiling of renal cell carcinoma tissue using gas chromatography met...

Background: Renal cell carcinoma (RCC) is marked by dysregulation of angiogenesis, energy metabolism, and nutrient sensing pathways [1]. This diversity is an obstacle to achieving long-term responses to treatment, notwithstanding progress in targeted and immunotherapeutic drugs. Objective: This study aimed to characterise the metabolic dysregulations that occur in RCC tissue using a metabolomics approach. Metho...

DNA methylation as a triage marker for colposcopy referral in HPV-based cervica...

Screening plays a key role in secondary prevention of cervical cancer. High-risk human papillomavirus (hrHPV) testing, a highly sensitive test but with limited specificity, has become the gold standard frontline for screening programs. Thus, the importance of effective triage strategies, including DNA methylation markers, has been emphasized. Despite the potential reported in individual studies, methylation mar...

Gal-3 Protein Expression and Localization in Prostate Tumours

Gal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promising diagnostic role of Gal-3 in the urine of PCa patients found in our previous study, its concordant gene and protein expression levels, and its involvement in PCa-rela...

Bladder wall stiffness after cystectomy in bladder cancer patients: a prelimina...

Bladder cancer (BlCa), specifically urothelial carcinomas, is a heterogeneous disease that derives from the urothelial lining. Two main classes of BlCa are acknowledged: the non-muscle invasive BlCa and the muscle-invasive BlCa; the latter constituting an aggressive disease which invades locally and metastasizes systemically. Distinguishing the specific microenvironment that cancer cells experience between muco...

The modulatory role of internet-supported mindfulness-based cognitive therapy o...

Mindfulness-based interventions (MBIs) have been used in oncology contexts as a promising tool with numerous benefits for various health-related and psychosocial outcomes. Despite the increasing popularity of MBIs, few randomized controlled trials (RCTs) have examined their effects upon biological parameters. Specifically, no previous study has examined the effects of MBIs on extracellular vesicles (EVs), which...

The modulatory role of internet-supported mindfulness-based cognitive therapy o...

Mindfulness-based interventions (MBIs) have been used in oncology contexts as a promising tool with numerous benefits for various health-related and psychosocial outcomes. Despite the increasing popularity of MBIs, few randomized controlled trials (RCTs) have examined their effects upon biological parameters. Specifically, no previous study has examined the effects of MBIs on extracellular vesicles (EVs), which...

Differential cellular effects of sunitinib and pazopanib targeted drugs for met...

Application of Proteogenomics to Urine Analysis towards the Identification of N...

To identify new protein targets for PCa detection, first, a shotgun discovery experiment was performed to characterize the urinary proteome of PCa patients. This revealed 18 differentially abundant urinary proteins in PCa patients. Second, selected targets were clinically tested by immunoblot, and the soluble E-cadherin fragment was detected for the first time in the urine of PCa patients. Third, the proteogeno...