11 documents found, page 1 of 2
Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation ...
Silva, Daniela Correia da; Jervis, Peter John; Martins, J. A. R.; Valentão, Patrícia; Ferreira, Paula M. T.; Pereira, David M.Fisetin (FST) is a dietary flavonol that is known to possess multiple relevant bioactivities, raising the question of its potential health benefits and even its use in novel pharmacological approaches. To attain this prospect, some limitations to this molecule, namely its poor bioavailability and solubility, must be addressed. Inflammation and endoplasmic reticulum (ER) stress are often hand in hand in the cont...
Hydrogels and nanostructures formed from ciprofloxacin–peptide conjugates
Jervis, Peter John; Baptista, Inês; Martins, Luciana; Pereira, David M.; Martins, J. A. R.; Ferreira, Paula M. T.Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic that possesses potent activity against both Gram-positive and Gram-negative bacteria and is used to treat many infections. Despite its widespread use, ciprofloxacin is associated with side effects, which might be reduced by improving its pharmacokinetic properties. The chemical structure of ciprofloxacin is the source of some of its limitations, which...
An injectable, naproxen-conjugated, supramolecular hydrogel with ultra-low crit...
Oliveira, Carlos Bruno Pereira; Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.; Figueiredo, Pedro R.; Carvalho, Alexandra T.P.; Hilliou, L.Short peptides capped on the N-terminus with aromatic groups are often able to form supramolecular hydrogels—self-assembled networks of fibrils able to trap water molecules. Typically, these hydrogelators can form stiff gels at concentrations of 0.1 to 1.0 wt%—i.e. they consist of mainly water. The properties of these soft materials mimic those of the extracellular matrix (ECM) of biological tissue and therefor...
Aryl-capped lysine-dehydroamino acid dipeptide supergelators as potential drug ...
Oliveira, Carlos B. P.; Pereira, Renato B.; Pereira, David M.; Hilliou, L.; Castro, Tarsila Gabriel; Martins, J. A. R.; Jervis, Peter JohnEmploying amino acids and peptides as molecular building blocks provides unique opportunities for generating supramolecular hydrogels, owing to their inherent biological origin, bioactivity, biocompatibility, and biodegradability. However, they can suffer from proteolytic degradation. Short peptides (<8 amino acids) attached to an aromatic capping group are particularly attractive alternatives for minimalistic ...
Hydrogels in regenerative medicine and other biomedical applications
Jervis, Peter John[Excerpt] It is my great pleasure to be part of this Special Issue in the International Journal of Molecular Sciences—“Hydrogels in Regenerative Medicine and Other Biomedical Applications”. Hydrogels are made up of three-dimensional matrices of hydrophilic polymers, which are held together by chemical or physical crosslinks or by supramolecular assemblies of smaller amphiphilic molecules.
Peptide-based supramolecular hydrogels as drug delivery agents: recent advances
Oliveira, Carlos Bruno Pereira; Gomes, Valéria; Ferreira, Paula M. T.; Martins, José A.; Jervis, Peter JohnSupramolecular peptide hydrogels have many important applications in biomedicine, including drug delivery applications for the sustained release of therapeutic molecules. Targeted and selective drug administration is often preferential to systemic drug delivery, as it can allow reduced doses and can avoid the toxicity and side-effects caused by off-target binding. New discoveries are continually being reported ...
Evaluation of a model photo-caged dehydropeptide as a stimuli-responsive supram...
Jervis, Peter John; Hilliou, L.; Pereira, Renato B.; Pereira, David M.; Martins, J. A. R.; Ferreira, Paula M. T.Short peptides capped on the <i>N</i>-terminus with aromatic groups are often able to form supramolecular hydrogels, via self-assembly, in aqueous media. The rheological properties of these readily tunable hydrogels resemble those of the extracellular matrix (ECM) and therefore have potential for various biological applications, such as tissue engineering, biosensors, 3D bioprinting, drug delivery systems and w...
Bolaamphiphilic Bis-Dehydropeptide hydrogels as potential drug release systems
Amorim, Carolina; Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.; Hilliou, L.; Pereira, Renato B.; Pereira, David M.; Martins, J. A.The self-assembly of nanometric structures from molecular building blocks is an effective way to make new functional materials for biological and technological applications. In this work, four symmetrical bolaamphiphiles based on dehydrodipeptides (phenylalanyldehydrophenylalanine and tyrosyldehydrophenylalanine) linked through phenyl or naphthyl linkers (terephthalic acid and 2,6-naphthalenedicarboxylic acid) ...
Dehydropeptide supramolecular hydrogels and nanostructures as potential peptido...
Jervis, Peter John; Amorim, Carolina; Pereira, Teresa; Martins, J. A. R.; Ferreira, Paula M. T.Supramolecular peptide hydrogels are gaining increased attention, owing to their potential in a variety of biomedical applications. Their physical properties are similar to those of the extracellular matrix (ECM), which is key to their applications in the cell culture of specialized cells, tissue engineering, skin regeneration, and wound healing. The structure of these hydrogels usually consists of a di- or tri...
Biological evaluation of naproxen–dehydrodipeptide conjugates with self-hydroge...
Moreira, Rute; Jervis, Peter John; Carvalho, André; Ferreira, Paula M. T.; Martins, J. A. R.; Valentão, Patrícia; Andrade, Paula B.; Pereira, David M.The use of peptide–drug conjugates is emerging as a powerful strategy for targeted drug delivery. Previously, we have found that peptides conjugated to a non-steroidal anti-inflammatory drug (NSAID), more specifically naproxen–dehydrodipeptide conjugates, readily form nanostructured fibrilar supramolecular hydrogels. These hydrogels were revealed as efficacious nano-carriers for drug delivery applications. More...