2 documents found, page 1 of 1
Biologicals in childhood severe asthma: the European PERMEABLE survey on the st...
Santos-Valente, E; Buntrock-Döpke, H; Abou Taam, R; Arasi, S; Bakirtas, A; Lozano Blasco, J; Bønnelykke, K; Craiu, M; Cutrera, R; Deschildre, AIntroduction: Severe asthma is a rare disease in children, for which three biologicals, anti-immunoglobulin E, anti-interleukin-5 and anti-IL4RA antibodies, are available in European countries. While global guidelines exist on who should receive biologicals, knowledge is lacking on how those guidelines are implemented in real life and which unmet needs exist in the field. In this survey, we aimed to investigate...
Targeted Gene Panel Sequencing for Early-onset Inflammatory Bowel Disease and C...
Petersen, BS; August, D; Abt, R; Alddafari, M; Atarod, L; Baris, S; Bhavsar, H; Brinkert, F; Buchta, M; Bulashevska, A; Chee, R; Cordeiro, AI; Dara, NBackground: In contrast to adult-onset inflammatory bowel disease (IBD), where many genetic loci have been shown to be involved in complex disease etiology, early-onset IBD (eoIBD) and associated syndromes can sometimes present as monogenic conditions. As a result, the clinical phenotype and ideal disease management in these patients often differ from those in adult-onset IBD. However, due to high costs and the...