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Immunophenotype of gastric tumors unveils a pleiotropic role of regulatory T ce...

Rocha, Sara; Basto, Afonso; Ijsselsteijn, Marieke E.; Teles, Sara P.; Azevedo, Maria M.; Gonçalves, Gilza; Gullo, Irene; Almeida, Gabriela M.

Gastric cancer (GC) patients display increased regulatory T cell (Tregs) numbers in peripheral blood and among tumor-infiltrating lymphocytes. Nevertheless, the role of Tregs in GC progression remains controversial. Here, we sought to explore the impact of Tregs in GCs with distinct histology, and whether Tregs can directly influence tumor cell behavior and GC development. We performed a comprehensive immunophe...

Date: 2021   |   Origin: Repositório da Universidade de Lisboa
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