6 documents found, page 1 of 1
Acute Iron Poisoning: A Frequently Underrated Event
Moreira da Cruz, Raquel; Cruz, Margarida; Sousa, Filipa; Ribeiro, Fani; Zão, Inês; Jesus, GoreteAcute iron poisoning is common and can be potentially severe.Early recognition is the key to a good prognosis. It canbe classified into mild, moderate or severe, according to clinicalmanifestations and serum iron levels. We report a case ofan 18-year-old female patient admitted with voluntary poisoningof 25 pills of ferrous sulphate. She manifested with nausea,vomit and diffuse abdominal pain, with normal physi...
IL10 low-frequency variants in Behçet's disease patients
Ramos De Matos, Mafalda; Xavier, Joana M; Abrantes, Patrícia; Sousa, Inês; Rei, Nádia; Davatchi, Fereydoun; Shahram, Farhad; Jesus, GoreteAim: To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's disease (BD) and the goal of this study is to investigate the role of low-frequency IL10 variants in BD susceptibility...
Gene expression profiling and association studies implicate the neuregulin sign...
Xavier, Joana M; Krug, Tiago; Davatchi, Fereydoun; Shahram, Farhad; Fonseca, Benedita V.; Jesus, Gorete; Barcelos, Filipe; Vedes, Joana; Salgado, ManuelBehçet's disease (BD) is a complex disease with genetic and environmental risk factors implicated in its etiology; however, its pathophysiology is poorly understood. To decipher BD's genetic underpinnings, we combined gene expression profiling with pathway analysis and association studies. We compared the gene expression profiles in peripheral blood mononuclear cells (PBMCs) of 15 patients and 14 matched contro...
Parsonage–Turner syndrome: a clinical case report
Jesus, Gorete; Neves, Clarinda; Rodrigues, Sandra; Oliveira, Anabela; Borralho, Teresa; Biléu, Maria do Castelo; Crespo, JorgeBrachial neuritis, Parsonage–Turner syndrome or neuralgic amyotrophy is an acute neuritis of the brachial plexus or isolated nerves, of unknown aetiology, commonly considered an immune mediated inflammatory process against nerve fibres, which has an annual incidence of 1.64 cases per 100,000 population. The authors report the case of a 59 year–old male with a pathological background of hypertension and hyperlip...
Hansen’s Disease- a disease being eradicated?
Rocha, Elsa; Jesus, Gorete; Neves, Clarinda; Sá, Dulcínea; Araújo, Eliana; Pinheiro, Beatriz; Borralho, Teresa; Geraldo, Pires; Fernandes, BárbaraLeprosy is an ancient chronic granulomatous disease caused by Mycobacterium leprae. Prevalence varies greatly from country to country and it represents an important public health problem in developing countries. Despite the efforts of the WHO to eradicate this disease, it has a prevalence greater than 1/10,000 in one group of fifteen countries, led by India and Brazil.Clinical features are skin lesions and sens...
Drug-induced hepatitis treated with corticosteroids – a clinical case report
Oliveira, Anabela; Rodrigues, Sandra; Jesus, Gorete; Jorge, RosaThe authors report the case of a 46 year-old female, with no relevant pathological background, who was prescribed cefuroxime axetil and nimesulide, and fi fteen days later, developed general malaise, asthenia, jaundice and coluria.On being hospitalized, the patient showed an increase of transaminases (ALT= 1747 UI/l) and hyperbilirubinaemia (total bil. = 4.6 mg/dl). As the condition evolved, the jaundice became...