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Brain-derived neurotrophic factor modulation in response to oxidative stress an...
Correia, Ana Salomé; Torrado, Marília; Costa-Coelho, Tiago; Carvalho, Eva Daniela; Inteiro-Oliveira, Sara; Diógenes, Maria José; Pêgo, Ana PaulaMajor Depressive Disorder (MDD) is a very complex disease, challenging to study and manage. The complexities of MDD require extensive research of its mechanisms to develop more effective therapeutic approaches. Crucial in the context of this disease is the role of brain-derived neurotrophic factor (BDNF) signaling pathway. Aim: This manuscript aims to explore the complex relationship between MDD and BDNF signal...
The present and the future of degradable dendrimers and derivatives in theranos...
Leiro, Victoria; Garcia, João Pedro; Tomás, Helena; Pêgo, Ana PaulaInterest in dendrimer-based nanomedicines has been growing recently, as it is possible to precisely manipulate the molecular weight, chemical composition, and surface functionality of dendrimers, tuning their properties according to the desired biomedical application. However, one important concern about dendrimer-based therapeutics remains-the nondegradability under physiological conditions of the most commonl...
Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by...
Bordeira-Carriço, Renata; Ferreira, Daniel; Mateus, Denisa D.; Pinheiro, Hugo; Pêgo, Ana Paula; Santos, Manuel A. S.; Oliveira, CarlaHereditary diffuse gastric cancer (HDGC) syndrome, although rare, is highly penetrant at an early age, and is severe and incurable because of ineffective screening tools and therapy. Approximately 45% of HDGC families carry germline CDH1/E-cadherin alterations, 20% of which are nonsense leading to premature protein truncation. Prophylactic gastrectomy is the only recommended approach for all asymptomatic CDH1 m...
A new strategy based on SmRho protein loaded chitosan nanoparticles as a candid...
Oliveira, Carolina R.; Rezende, Cíntia M. F.; Silva, Marina R.; Pêgo, Ana Paula; Borges, Olga; Goes, Alfredo M.Background: Schistosomiasis is one of the most important neglected tropical diseases and an effective control is unlikely in the absence of improved sanitation and vaccination. A new approach of oral vaccination with alginate coated chitosan nanoparticles appears interesting because their great stability and the ease of target accessibility, besides of chitosan and alginate immunostimulatory properties. Here we...
Cancer syndromes and therapy by stop-codon readthrough
Bordeira-Carriço, Renata; Pêgo, Ana Paula; Santos, Manuel; Oliveira, CarlaSeveral hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as aminoglycosides and PTC124 have exhibited promising results for treating patients with cystic fibrosis and Duchenne m...
Osteogenic differentiation of mesenchymal stem cells using PAMAM dendrimers as ...
Santos, José Luís; Oramas, Elena; Pêgo, Ana Paula; Granja, Pedro Lopes; Tomás, HelenaThis paper reports the use of different generations of polyamidoamine (PAMAM) dendrimers for the in vitro transfection of mesenchymal stem cells (MSCs). A systematic study was carried out on the transfection efficiency achieved by the PAMAM dendrimers using a beta-galactosidase reporter gene system. Transfection results were shown to be dependent upon the generation of dendrimers, the amine to phosphate group r...