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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Diso...

Mullins, Niamh; Kang, JooEun; Campos, Adrian I; Coleman, Jonathan R I; Edwards, Alexis C; Galfalvy, Hanga; Levey, Daniel F; Lori, Adriana

Background: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) c...


Impact of COVID-19 lockdown in eating disorders: a multicentre collaborative in...

Baenas, Isabel; Etxandi, Mikel; Munguía, Lucero; Granero, Roser; Mestre-Bach, Gemma; Sánchez, Isabel; Ortega, Emilio; Andreu, Alba; Moize, Violeta L.

Background. The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable. Aims. (1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography. Methods. Th...


COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in e...

Fernandez-Aranda, Fernando; Munguia, Lucero; Mestre-Bach, Gemma; Steward, Trevor; Etxandi, Mikel; Baenas, Isabel; Granero, Roser; Sanchez, Isabel

Confinement during the COVID-19 pandemic is expected to have a serious and complex impact on the mental health of patients with an eating disorder (ED) and of patients with obesity. The present manuscript has the following aims: (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; and (3) to explo...


A multimodal MRI study of the neural mechanisms of emotion regulation impairmen...

Steward, Trevor; Picó-Pérez, Maria; Mestre-Bach, Gemma; Martínez-Zalacaín, Ignacio; Suñol, Maria; Jiménez-Murcia, Susana; Fernández-Formoso, Jose A.

Maladaptive emotion regulation contributes to overeating and impedes weight loss. Our study aimed to compare the voluntary downregulation of negative emotions by means of cognitive reappraisal in adult women with obesity (OB) and female healthy controls (HC) using a data-driven, multimodal magnetic resonance imaging (MRI) approach. Women with OB (n = 24) and HC (n = 25) carried out an emotion regulation task du...


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