6 documents found, page 1 of 1
Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
Silva,Rodrigo M. da; Guaratini,Thais; Jimenez,Paula C.; Fenical,William; Costa-Lotufo,Letícia V.; Vessecchi,Ricardo; Lopes,Norberto P.Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/M...
Bioprospecting Anticancer Compounds from the Marine-Derived Actinobacteria Acti...
Silva,Amaro E. T.; Guimarães,Larissa A.; Ferreira,Elthon G.; Torres,Maria da Conceição M.; Silva,Alison B. da; Branco,Paola C.The actinomycete strain BRA 177 was recovered from sediment samples collected at the St. Peter and St. Paul Archipelago, Brazil. This work accessed the ability of this strain, identified as Actinomadura sp., to produce bioactive metabolites by exploring the genome and characterizing chemistry and cytotoxicity of isolated compounds. From the crude ethyl acetate extract, the pigments nonylprodigiosin, cyclononylp...
Amphidinolide P from the Brazilian octocoral Stragulum bicolor
Sousa,Thiciana S.; Nuzzo,Genoveffa; Torres,Maria C.M.; Lopes,Norberto P.; Cutignano,Adele; Jimenez,Paula C.; Santos,Evelyne A.; Gomes,Bruno A.Abstract Dinoflagellates are an important source of unique bioactive secondary metabolites. Symbiotic species, commonly named zooxanthellae, transfer most of their photosynthetically fixed carbon to their host. The mutualistic relationship provides the organic metabolites used for energy production but there are very few reports of the role of the dinoflagellates in the production of secondary metabolites in th...
Perezone, from the gorgonian Pseudopterogorgia rigida, induces oxidative stress...
Abreu,Paula A.; Wilke,Diego V.; Araujo,Ana J.; Marinho-Filho,José Delano B.; Ferreira,Elthon G.; Ribeiro,Carlos Margo R.; Pinheiro,Leandro S.Abstract Four bisabolanes 1–4, including perezone (1) and triacetyl perezone (2), were isolated through a bioassay-guided fractionation of the extract obtained from the Caribbean gorgonian coral Pseudopterogorgia rigida collected during an expedition cruise to the Bahamas. All isolated compounds showed to be cytotoxic toward panel of four human tumor cell lines, as quantified by the MTT assay after 72 h incubat...
Systematic UPLC-ESI-MS/MS study on the occurrence of staurosporine and derivati...
Andréo,Márcio A.; Jimenez,Paula C.; Siebra,Josy B. C. N.; Costa-Lotufo,Leticia V.; Vessecchi,Ricardo; Niehues,Michael; Lopes,João L. C.Former bioactivity-guided analysis of the marine invertebrate Eudistoma vannamei led to the isolation of staurosporine derivatives, which revealed strong cytotoxic activity against several human cancer cell lines. The occurrence of such alkaloids in E. vannamei may be correlated to the presence of associated biota, such as Streptomyces bacteria. In agreement to this hypothesis, marine microorganisms associated ...
Sample optimization for rapid identification of nucleosides and bases from asci...
Takeara,Renata; Jimenez,Paula C.; Costa-Lotufo,Letícia V.; Lopes,João L. C.; Lopes,Norberto P.Electrospray ionization tandem mass spectrometry (ESI-MS/MS) method was developed for identification of nucleosides and bases in extracts of ascidians. For this study a systematic sample preparation associated with the fragmentation pattern of a series of nucleosides and bases using ESI-MS/MS was done. These approaches constitute powerful analytical tools for rapid screening and structural assignment of nucleos...