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Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons...
João, Bessa; Morais, Mónica; Marques, Fernanda; Pinto, Luísa; Palha, Joana Almeida; Sousa, NunoThere is accumulating evidence that the nucleus accumbens (NAc) has an important role in the pathophysiology of depression. As the NAc is a key component in the neural circuitry of reward, it has been hypothesized that anhedonia, a core symptom of depression, might be related to dysfunction of this brain region. Neuronal morphology and expression of plasticity-related molecules were examined in the NAc of rats ...
Date: 2013
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Origin: RepositóriUM - Universidade do Minho