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Lycopene-rich extract from red guava ( Psidium guajava L.) displays cytotoxic e...

Santos, Raimunda C. dos; Ombredane, Alicia S.; Souza, Jéssica Maria T.; Vasconcelos, Andreanne G.; Plácido, Alexandra; Amorim, Adriany das G.N.

This study investigated a lycopene-rich extract from red guava (LEG) for its chemical composition using spectrophotometry, mass spectrometry, attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), and computational studies. The cytotoxic activity of LEG and the underlying mechanism was studied in human breast adenocarcinoma cells (MCF-7), murine fibroblast cells (NIH-3T3), BALB/c murin...


Structure and function of a novel antioxidant peptide from the skin of tropical...

Barbosa, Eder Alves; Oliveira, Ana; Plácido, Alexandra; Socodato, Renato; Portugal, Camila C.; Mafud, Ana Carolina; Ombredane, Alicia S.

The amphibian skin plays an important role protecting the organism from external harmful factors such as microorganisms or UV radiation. Based on biorational strategies, many studies have investigated the cutaneous secretion of anurans as a source of bioactive molecules. By a peptidomic approach, a novel antioxidant peptide (AOP) with in vitro free radical scavenging ability was isolated from Physalaemus natter...


Quaternized cashew gum: An anti-staphylococcal and biocompatible cationic polym...

Quelemes, Patrick V.; Araújo, Alyne R. de; Plácido, Alexandra; Delerue-Matos, Cristina; Maciel, Jeanny S.; Bessa, Lucinda J.; Ombredane, Alicia S.

Chemical modifications to cashew gum (CG) structure have been previously reported to obtain new physicochemical characteristics, however until now there were no reports of modifications by introduction of new functional groups to add cationic character. This study presents a quaternization route for CG using a quaternary ammonium reagent. The chemical features of the quaternized cashew gum derivatives (QCG) wer...


Quaternized cashew gum: An anti-staphylococcal and biocompatible cationic polym...

Quelemes, Patrick V.; Araújo, Alyne R. de; Plácido, Alexandra; Delerue-Matos, Cristina; Maciel, Jeanny S.; Bessa, Lucinda J.; Ombredane, Alicia S.

Chemical modifications to cashew gum (CG) structure have been previously reported to obtain new physicochemical characteristics, however until now there were no reports of modifications by intro-duction of new functional groups to add cationic character. This study presents a quaternization route for CG using a quaternary ammonium reagent. The chemical features of the quaternized cashew gum derivatives (QCG) were...


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