4 documents found, page 1 of 1
Genes related to maintenance of autophagy and successful aging
Chaves,Carolina Fioroto; Mazzotti,Diego Robles; Cendoroglo,Maysa Seabra; Ramos,Luiz Roberto; Tufik,Sergio; Silva,Vanessa Cavalcante da; D'Almeida,VâniaABSTRACT Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carried out in peripheral blood, and the proteasome quantification was performed in plasma. No significant changes ...
Homocysteine and Psychiatric Disorders
Silva,Vanessa Cavalcante da; Oliveira,Allan Chiaratti de; D’Almeida,VâniaAbstract Psychiatric disorders are highly prevalent all over the world with a great impact on public health. Altered homocysteine metabolism is implicated in the pathogenesis of many of these disorders, as it can interfere in normal methylation of subcellular components, promote neuroexcitotoxicity, and induce oxidative stress and inflammation. There are cumulative data implicating these mechanisms in the devel...
APOE-ε4 polymorphism and cognitive deficit among the elderly population of Fern...
Garcia,Anália Nusya; Silva,Helker Albuquerque da; Silva,Renan Carlos; Leal,Eliane Maria Medeiros; Rodrigues,Lorena; Silva,Vanessa Cavalcante daBACKGROUND: Polymorphism of the gene for apolipoprotein E (APOE) is an important risk factor for the development of Alzheimer's disease. The ε4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations. OBJECTIVE: To identify APOE-ε4 polymorphism and correlate this with cognitive deficit among the elderly population of th...
Alzheimer's disease in Brazilian elderly has a relation with homocysteine but n...
Silva,Vanessa Cavalcante da; Ramos,Flávio José da Costa; Freitas,Elizabete Malaquias; Brito-Marques,Paulo Roberto de; Cavalcanti,Márcia Nery de HolandaOBJECTIVE: To investigate the association between total plasma homocysteine concentration, C677T and A1298C polymorphisms in MTHFR gene and Alzheimer's disease (AD) development. METHOD: Forty-three patients with probable (63%) and possible (37%) AD and 50 non-demented controls were evaluated. Groups did not differ as to gender, age, scholar years, diabetes, alcohol and coffee intake and physical activity. Total...