5 documents found, page 1 of 1
Compounds altering fat storage in Daphnia magna
Jordão, Rita; Garreta, Elba; Campos, Bruno; Lemos, Marco; Soares, Amadeu M.V.M.; Tauler, Romà; Barata, CarlosThe analysis of lipid disruptive effects in invertebrates is limited by our poor knowledge of the lipid metabolic pathways. A recent study showed that tributyltin activated the ecdysteroid, juvenile hormone and retinoic X receptor signaling pathways, and disrupted the dynamics of neutral lipids in the crustacean Daphnia magna impairing the transfer of triacylglycerols to eggs and hence promoting their accumulat...
Induction of multixenobiotic defense mechanisms in resistant Daphnia magna clon...
Jordão, Rita; Campos, Bruno; Lemos, Marco; Soares, Amadeu M.V.M.; Tauler, Romà; Barata, CarlosMultixenobiotic resistance mechanisms (MXR) were recently identified in Daphnia magna. Previous results characterized gene transcripts of genes encoding and efflux activities of four putative ABCB1 and ABCC transporters that were chemically induced but showed low specificity against model transporter substrates and inhibitors, thus preventing us from distinguishing between activities of different efflux transpo...
Obesogens beyond Vertebrates: Lipid Perturbation by Tributyltin in the Crustace...
Jordão, Rita; Casas, Josefina; Fabrias, Gemma; Campos, Bruno; Piña, Benjamín; Lemos, Marco; Soares, Amadeu M V M; Tauler, Romà; Barata, CarlosThe analysis of obesogenic effects in invertebrates is limited by our poor knowledge of the regulatory pathways of lipid metabolism. Recent data from the crustacean Daphnia magna points to three signaling hormonal pathways related to the molting and reproductive cycles [retinoic X receptor (RXR), juvenile hormone (JH), and ecdysone] as putative targets for exogenous obesogens. Objective: The present study addre...
Obesogens beyond vertebrates: lipid perturbation by tributyltin in the crustace...
Jordão, Rita; Casas, Josefina; Fabrias, Gemma; Campos, Bruno; Pina, Benjamín; Lemos, Marco F. L.; Soares, Amadeu M. V. M.; Tauler, Romà; Barata, CarlosBackground: The analysis of obesogenic effects in invertebrates is limited by our poor knowledge of the regulatory pathways of lipid metabolism. Recent data from the crustacean Daphnia magna points to three signaling hormonal pathways related to the molting and reproductive cycles [retinoic X receptor (RXR), juvenile hormone (JH), and ecdysone] as putative targets for exogenous obesogens. Objective: The present...
Two-generational effects of contaminants in Daphnia magna : Effects of offsprin...
Campos, Bruno; Jordão, Rita; Rivetti, Claudia; Lemos, Marco; Soares, Amadeu; Tauler, Roma; Barata, CarlosThe authors set up a protocol to perform a 2-generational ring test using the existing guidelines for the Daphnia magna reproduction test. It is well known in ecology that size and quality of offspring vary across the first clutches in D. magna and that certain chemicals affect offspring quality. Therefore, the origin of the second generation is an important factor to consider. Two-generational effects across f...