22 documents found, page 1 of 3
Influence of genetic variants of oxidative stress related genes on prognosis an...
Alves, Raquel; Ventura, Filipa; Jorge, Joana; Ribeiro, Ilda P.; Marques, Gilberto; Coucelo, Margarida; Diamond, Joana; Freitas-Tavares, PauloChronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of BCR-ABL1 oncogene. Oxidative stress conditions are crucial in tumor development and progression. The NRF2, codified by NFE2L2 gene, plays a central role in redox balance, promoting the transcription of cytoprotective and antioxidant genes such as SOD2, GPX1 and CAT. The action of this transcription factor is regulat...
Genetic variants in oxidative stress-related genes and their impact on prognosi...
Alves, Raquel; Ventura, Filipa; Jorge, Joana; Marques, Gilberto; Coucelo, Margarida; Diamond, Joana; Oliveiros, Bárbara; Pereira, AméliaChronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia characterized by the BCR::ABL1 fusion gene, which codifies the BCR-ABL protein with increased tyrosine kinase activity. Despite the clinical results for the outstanding tyrosine kinase inhibitors (TKIs), drug resistance is a problem in CML management. Genetic variants that alter redox homeostasis by changing antioxidant enzyme expression or...
Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plect...
Magalhães, Mariana; Domínguez-Martín, Eva María; Jorge, Joana; Gonçalves, Ana Cristina; Massenzio, Francesca; Spigarelli, RenatoGlioblastoma (GB) is the most aggressive and prevalent glioma within the central nervous system. Despite considerable efforts, GB continues to exhibit a dismal 5-year survival rate (∼6%). This is largely attributed to unfavorable prognosis and lack of viable treatment options. Therefore, novel therapies centered around plant-derived compounds emerge as a compelling avenue to enhance patient survival and well-be...
Batimastat Induces Cytotoxic and Cytostatic Effects in In Vitro Models of Hemat...
Alves, Raquel; Pires, Ana; Jorge, Joana; Balça-Silva, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana BelaThe role of metalloproteinases (MMPs) in hematological malignancies, like acute myeloid leukemia (AML), myelodysplastic neoplasms (MDS), and multiple myeloma (MM), is well-documented, and these pathologies remain with poor outcomes despite treatment advancements. In this study, we investigated the effects of batimastat (BB-94), an MMP inhibitor (MMPi), in single-administration and daily administration schemes i...
Batimastat Induces Cytotoxic and Cytostatic Effects in In Vitro Models of Hemat...
Alves, Raquel; Pires, Ana; Jorge, Joana; Balça-Silva, Joana; Gonçalves, Ana Cristina; Sarmento Ribeiro, Ana BelaThe role of metalloproteinases (MMPs) in hematological malignancies, like acute myeloid leukemia (AML), myelodysplastic neoplasms (MDS), and multiple myeloma (MM), is well-documented, and these pathologies remain with poor outcomes despite treatment advancements. In this study, we investigated the effects of batimastat (BB-94), an MMP inhibitor (MMPi), in single-administration and daily administration schemes i...
Screening for Autism Spectrum Disorders - Validation of the Portuguese Version ...
Araújo, Manuela; Jorge, Joana; Santos, Maria do Carmo; Vilhena, Estela; Oliveira, Pedro; Freitas, Paula PintoThere are no assessment and screening tools for Autism Spectrum Disorders (ASD) validated for the Portuguese population. The Social Communication Questionnaire (SCQ) is an useful screening tool of ASD diagnosis. The main objectives of our study were to produce a Portuguese version of the SCQ (SCQ-PF), study its internal consistency, sensitivity and specificity in order to evaluate its validity as a screening in...
Platelet Membrane Proteins as Pain Biomarkers in Patients with Severe Dementia
Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Veríssimo, Manuel T.; Dourado, MaríliaPain is one of the most frequent health problems, and its evaluation and therapeutic approach largely depend on patient self-report. When it is not possible to obtain a self-report, the therapeutic decision becomes more difficult and limited. This study aims to evaluate whether some membrane platelet proteins could be of value in pain characterization. To achieve this goal, we used 53 blood samples obtained fro...
Alvespimycin Inhibits Heat Shock Protein 90 and Overcomes Imatinib Resistance i...
Alves, Raquel; Santos, Diogo; Jorge, Joana; Gonçalves, Ana Cristina; Catarino, Steve; Girão, Henrique; Melo, Joana Barbosa; Sarmento-Ribeiro, Ana BelaHeat shock protein 90 (HSP90) facilitates folding and stability and prevents the degradation of multiple client proteins. One of these HSP90 clients is BCR-ABL, the oncoprotein characteristic of chronic myeloid leukemia (CML) and the target of tyrosine kinase inhibitors, such as imatinib. Alvespimycin is an HSP90 inhibitor with better pharmacokinetic properties and fewer side effects than other similar drugs, b...
Monocytes in the Characterization of Pain in Palliative Patients with Severe De...
Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Veríssimo, Manuel T.; Andrade, José PauloIn assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive peripheral biomarkers in identifying and characterizing pain in patients with severe dementia. We used 53 blood samp...
Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies
Jorge, Joana; Neves, Joana; Alves, Raquel; Geraldes, Catarina; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana BelaLymphoid malignancies are a group of highly heterogeneous diseases frequently associated with constitutive activation of the nuclear factor kappa B (NF-κB) signaling pathway. Parthenolide is a natural compound used to treat migraines and arthritis and found to act as a potent NF-κB signaling inhibitor. This study evaluated in vitro parthenolide efficacy in lymphoid neoplasms. We assessed parthenolide metabolic ...