6 documents found, page 1 of 1
Computational Insights into the Interplay of Mechanical Forces in Angiogenesis
Guerra, A; Belinha, J; Salgado, CL; Monteiro, FJ; Jorge, RNThis study employs a meshless computational model to investigate the impacts of compression and traction on angiogenesis, exploring their effects on vascular endothelial growth factor (VEGF) diffusion and subsequent capillary network formation. Three distinct initial domain geometries were defined to simulate variations in endothelial cell sprouting and VEGF release. Compression and traction were applied, and t...
A Comprehensive Look at In Vitro Angiogenesis Image Analysis Software
Pereira, M; Pinto, J; Arteaga, B; Guerra, A; Jorge, RN; Monteiro, FJ; Salgado, CLOne of the complex challenges faced presently by tissue engineering (TE) is the development of vascularized constructs that accurately mimic the extracellular matrix (ECM) of native tissue in which they are inserted to promote vessel growth and, consequently, wound healing and tissue regeneration. TE technique is characterized by several stages, starting from the choice of cell culture and the more appropriate ...
Association Between Physical Activity Level and Pelvic Floor Muscle Variables i...
Carvalhais, A; Da Roza, T; Vilela, S; Jorge, RN; Bo, KIn order to investigate the potential impact of physical activity (PA) on pelvic floor muscle (PFM) function, a cross-sectional study was made to analyse the association between PA level and vaginal resting pressure (VRP) and PFM strength and endurance. Thirty-eight continent women and 20 women with stress urinary incontinence (SUI) aged 19 to 49 years were enrolled in the study. PFM variables were assessed by ...
Effects of the fibers distribution in the human eardrum: A biomechanical study
Gentil, F; Parente, M; Martins, P; Garbe, C; Santos, C; Areias, B; Branco, C; Paço, J; Jorge, RNThe eardrum separates the external ear from the middle ear and it is responsible to convert the acoustical energy into mechanical energy. It is divided by pars tensa and pars flaccida. The aim of this work is to analyze the susceptibility of the four quadrants of the pars tensa under negative pressure, to different lamina propria fibers distribution. The development of associated ear pathology, in particular th...
Effects of the fibers distribution in the human eardrum: A biomechanical study
Gentil, F; Parente, M; Martins, P; Garbe, C; Santos, C; Areias, B; Branco, C; Paço, J; Jorge, RNThe eardrum separates the external ear from the middle ear and it is responsible to convert the acoustical energy into mechanical energy. It is divided by pars tensa and pars flaccida. The aim of this work is to analyze the susceptibility of the four quadrants of the pars tensa under negative pressure, to different lamina propria fibers distribution. The development of associated ear pathology, in particular th...
The influence of muscles activation on the dynamical behaviour of the tympano-o...
Gentil, F; Parente, M; Martins, P; Garbe, C; Paço, J; Ferreira, AJ; Tavares, JM; Jorge, RNThe human ear is a complex biomechanical system and is divided into three parts: outer, middle and inner ear. The middle ear is formed by ossicles (malleus, incus and stapes), ligaments, muscles and tendons, which transfers sound vibrations from the eardrum to the inner ear, linking with mastoid and Eustachian tube. In this work, a finite element modelling of the tympano-ossicular system of the middle ear was d...