5 documents found, page 1 of 1
In vitro studies on Bothrops venoms cytotoxic effect on tumor cells
Jorge, Roberta J. B.; Martins, Alice M. C.; Morais, Isabel C. O.; Ximenes, Rafael M.; Rodrigues, Felipe A. R.; Soares, Bruno M.Made available in DSpace on 2022-04-29T02:17:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-29; Background: Animal venoms are complex mixtures of proteins and non proteins components with several biological activities. Snake venoms represent an essentially unexplored source of bioactive compounds that may cure disease conditions which do not respond to currently available therapies. These venoms p...
Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root ext...
Alves, Natacha Teresa Queiroz; Ximenes, Rafael M.; Jorge, Roberta J. B.; Silveira, J. A. M.; Santos, J. V. A.; Rodrigues, F. A. P.; Costa, P. H. S.Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, and anti-edematogenic ...
L-Aminoacid oxidase from Bothropsleucurus Venom induces nephrotoxicity via apop...
Morais, Gustavo J. S.; Orzáez, M.; Jorge, Roberta J. B.; Bincoletto, Claudia; Toyama, Marcos H.; Monteiro, Helena S. A.; Smaili, Soraya S.Acute renal failure is a common complication caused by Bothrops viper envenomation. In this study, the nefrotoxicity of a main component of B . leucurus venom called L-aminoacid oxidase (LAAO- Bl ) was evaluated by using tubular epithelial cell lines MDCK and HK-2 and perfused kidney from rats. LAAO- Bl exhibited cytotoxicity, inducing apoptosis and necrosis in MDCK and HK-2 cell lines in a concentration-depend...
L-Aminoacid oxidase from bothrops leucurus venom Induces nephrotoxicity via apo...
Morais, Isabel C. O.; Pereira, Gustavo J. S.; Orzáez, M.; Jorge, Roberta J. B.; Bincoletto, Claudia; Toyama, Marcos H. [UNESP]; Monteiro, Helena S. A.Made available in DSpace on 2015-12-07T15:33:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2015. Added 1 bitstream(s) on 2015-12-07T15:53:26Z : No. of bitstreams: 1 PMC4508040.pdf: 3122617 bytes, checksum: eefcb7bc8aa0ae64a01eff72ad743fb7 (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquis...
Peripheral antinociception and anti-edematogenic effect of a sulfated polysacch...
Quinderé, Ana L. G.; Fontes, Bruno P.; Vanderlei, Edfranck de S. O.; Rodrigues, José A. G.; Araújo, Ianna W. F. de; Jorge, Roberta J. B.Background: Sulfated polysaccharides from red marine algae have presented a variety of potentially therapeutic biological effects, however, their antinocicpetive and anti-inflammatory properties are not well understood. Methods: Male Swiss mice were pretreated with a sulfated polysaccharidic fraction obtained from the marine alga Acanthophora muscoides (AmII) (1, 3 or 9 mg/kg, iv) 30 min prior to either receivi...