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Vitamin K Epoxide Reductase Complex (VKORC1) Electrochemical Genosensors: Towar...
Barbosa, Tiago; Morais, Stephanie L.; Carvalho, Renato; Magalhães, Júlia M. C. S.; Domingues, Valentina F.; Delerue-Matos, CristinaAnticoagulants, including warfarin, are often administered to patients who are exhibiting early symptoms of thromboembolic episodes or who have already experienced such episodes. However, warfarin has a limited therapeutic index and might cause bleeding and other clinical problems. Warfarin inhibits the vitamin K epoxide reductase complex subunit 1 (VKORC1), an enzyme essential for activating vitamin K, in the ...
Warfarin pharmacogenomics: Designing electrochemical DNA-based sensors to detec...
Barbosa, Tiago; Morais, Stephanie L.; Pereira, Eduarda; Magalhães, Júlia M. C. S.; Domingues, Valentina F.; Ferreira-Fernandes, Hygor; Pinto, GiovannyThe CYP2C9 enzyme is involved in the metabolism of warfarin. The CYP2C9 gene harbors several single-nucleotide polymorphisms (SNPs), including CYP2C9*2 (rs1799853), which is known to affect warfarin’s therapeutic response. So, it is important to develop analytical tools capable of genotyping these SNPs to adjust warfarin’s therapeutic outcomes. In this work, an electrochemical DNA-based sensor was constructed a...
Differences between sexes in dynamic balance assessed with the Y-balance test (...
Sampaio, Tatiana; Oliveira, João; Barbosa, Tiago; Marinho, Daniel; Forte, Pedro; Morais , JorgeSwimming requires a significant amount of strength and upper body endurance, as well as shoulder mobility and stability. The Y-balance test is a land-based assessment that requires minimal equipment and examines the unilateral upper-body performance of athletes in their final range of motion to maintain stability (Gorman, Butler, Plisky, & Kiesel, 2012). Therefore, the aim of this study was to investigate diffe...
Validation of the Aquanex system to assess in-water forces during aquatic exercise
Santos, Catarina; Costa, Mário; Almeida, Daniel; Garrido, Nuno; Barbosa, Tiago; Rosa, SérgioThe aim of this study was to perform a validation of the Aquanex system to assess in-water forces during aquatic exercise. One sensor (Type A) that composes the differential pressure system (Aquanex v.4.1, STR, USA) was placed inside a wind tunnel (Axial Propellor Fan, England), this last being considered as the gold standard technique for measurement. A frequency inverter was used to control a range of twenty-...
Prevenção de úlceras de pressão em utentes de equipas de cuidados continuados i...
Barbosa, TiagoAs UP são consideradas um problema de saúde pública em Portugal e traduzem-se num indicador de qualidade dos cuidados de saúde prestados. Estima-se que 95% das UP são evitáveis; Consultados os indicadores da equipa do Cartaxo, identifica-se necessidade de intervenção nesta área. Neste sentido, desenvolveu-se uma Scoping Review, com a questão: Quais as estratégias de intervenção de enfermagem para prevenção de Ú...
The Effectiveness of a Dry-Land Shoulder Rotators Strength Training Program in ...
Batalha, Nuno; Paixão, Carlos; Silva, António; Costa, Mário; Mullen, John; Barbosa, TiagoCompetitive swimmers usually undergo large mileage of daily training, in which propulsive force is produced mainly by the upper limbs. Some studies claim that dry-land shoulder rotators injury prevention programs before the in-water swim practice are paramount. However, the effect of shoulder strengthening prior to water training is unclear. This study aimed to analyse the acute effects of training programs con...
Diminishing surgeon’s radiation exposure in percutaneous forefoot deformity sur...
Xará-Leite, Francisco; Carrapatoso, Manuel; Videira, Sara; Barbosa, Tiago; Rodrigues, Cláudia; Gonçalves, Isabel; Costa, LuísExposure to ionizing radiation entails health risks to the medical staff. In minimally invasive orthopedic foot surgery, this can become a particularly important aspect, due to patient and surgeon positioning relative to the x-ray source. While using the ‘classical’ positioning of patient, C-arm and surgical team disregards some of the most basic principles of self-safety, particularly in those centres with lim...
The coaches' perceptions and experience implementing a long-term athletic devel...
Costa, Mário; Santos, Catarina Costa; Quinta-Nova, L.C.; Costa, Aldo M.; Silva, António; Barbosa, TiagoThe aim of this study was to analyze the association between coaches’ experience and their perceptions on the implementation of a long-term athletic development (LTAD) model created in 2016 by the Portuguese Swimming Federation. Eighty-six swimming coaches were assembled in groups according to their experience level: “novice” (n = 24), “intermediate” (n = 26), and “experienced” (n = 36), and they answered a que...
Diminuição da exposição do cirurgião à radiação na cirurgia de ante-pé - posici...
Xará-Leite, Francisco; Videira, Sara; Carrapatoso, Manuel; Barbosa, Tiago; Rodrigues, Claudia; Gonçalves, Isabel; Costa, LuisA exposição à radiação ionizante acarreta riscos para a saúde das equipas médicas. Este aspeto é particularmente relevante na cirurgia minimamente invasiva do pé devido ao posicionamento do doente e do cirurgião relativamente à fonte de radiação X. Durante o posicionamento “clássico” do doente, o C-arm e a equipa desconsideram alguns dos mais elementares princípios de segurança, particularmente nos centros com ...
Dietary intake of young Portuguese handball players
de Sá, Carla; Monteiro, Sérgio; Osório, Sofia; Barbosa, Tiago; Sá, PauloThe aim of this study was to analyse dietary intake (macronutrients and micronutrients) in young female and male handball athletes. A transversal study was performed with young handball players from sub 16 and 18 Portuguese Handball Federation, who volunteered to participate in this study. Anthropometric (weight and height measure), nutritional intake (using food frequency questionnaire) and position in the gam...