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Polymers enhancing bioavailability in drug delivery

Fernandes, Ana Isabel; Jozala, Angela Faustino


Laboratory animal welfare: environmental enrichment shows positive effect on an...

Massari, Catia Helena de Almeida Lima; Martins, Nadini Oliveira; Jozala, Angela Faustino; Grotto, Denise; Gerenutti, Marli

Reproductive and developmental toxicology has focused on the need to approach the effects of organism exposure to various drugs during pregnancy after the mid-50’s, when the thalidomide tragedy stroke humanity. In recent decades, this area of study has developed a lot due to animal testing, raising awareness on the need to improve the quality of life of such animals. Therefore, this paper aims to investigate ho...

Date: 2019   |   Origin: Oasisbr

Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscre...

Cefali, Letícia Caramori; Ataide, Janaína Artem; Fernandes, Ana Rita; Sousa, Ilza Maria de Oliveira; Gonçalves, Fernanda Cristina da Silva

The aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant effect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor, antioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids were evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial analysis after loading the blend ...


Modified-release topical hydrogels: a ten-year review

Croisfelt, Fernanda M.; Tundisi, Louise Lacalendola; Ataide, Janaína Artem; Silveira, Edgar; Tambourgi, Elias Basile; Jozala, Angela Faustino

Hydrogels are polymeric networks with tridimensional structure, which are able to load water and other substances. Such property makes hydrogels suitable for innumerous applications in biomedical field. Hydrogels are being used as raw materials in pharmaceutical formulations for more than 60 years, while significant progress is very well documented in topical use. Natural and synthetic polymers have been applie...


Flavonoid-enriched plant-extract-loaded emulsion: a novel phytocosmetic sunscre...

Cefali, Letícia Caramori; Ataide, Janaína Artem; Fernandes, Ana Rita; Sousa, Ilza Maria de Oliveira; Gonçalves, Fernanda Cristina da Silva

The aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant effect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor, antioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids were evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial analysis after loading the blend ...


Effect of polysaccharide sources on the physicochemical properties of bromelain...

Ataide, Janaína Artem; Gérios, Eloah Favero; Cefali, Letícia Caramori; Fernandes, Ana Rita; Teixeira, Maria do Céu; Ferreira, Nuno R.

Bromelain, a set of proteolytic enzymes potential pharmaceutical applications, was encapsulated in chitosan nanoparticles to enhance enzyme stability, and the effect of different chitosan sources was evaluated. Chitosan types (i.e., low molecular weight chitosan, chitosan oligosaccharide lactate, and chitosan from shrimp shells) produced nanoparticles with different physicochemical properties, however in all ca...


Biomolecules extracted by ATPs: practical examples

Molino, João Vitor Dutra; Feitosa, Valker A.; Novaes, Leticia Celia de Lencastre; Ebinuma, Valéria de Carvalho Santos [UNESP]; Lopes, André Moreni

Made available in DSpace on 2016-01-28T16:55:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2016-01-28T17:02:28Z : No. of bitstreams: 1 ISSN1665-2738-2014-13-02-359-377.pdf: 4166382 bytes, checksum: 4c8c484bf7cceeef47bb923038908503 (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselh...

Date: 2016   |   Origin: Oasisbr

Bacterial cellulose production by Gluconacetobacter xylinus by employing altern...

Jozala, Angela Faustino; Pértile, Renata Aparecida Nedel; Santos, Carolina Alves dos; Ebinuma, Valéria de Carvalho Santos; Seckler, Marcelo Martins

Bacterial cellulose (BC) is used in different fields as a biological material due to its unique properties. Despite there being many BC applications, there still remain many problems associated with bioprocess technology, such as increasing productivity and decreasing production cost. New technologies that use waste from the food industry as raw materials for culture media promote economic advantages because th...


The influence of pH, polyethylene glycol and polyacrylic acid on the stability ...

Novaes, Letícia Celia de Lencastre; Jozala, Angela Faustino; Mazzola, Priscila Gava; Júnior, Adalberto Pessoa

Enzyme stability is critical in biotechnology, pharmaceutical and cosmetic industries. Investigations on this subject have drawn attention because of its practical application. Bromelain is a thiol-endopeptidase, obtained from pineapple (Ananas comosus), known for its clinical and therapeutic applications, particularly to selective burn debridement and improvement of antibiotic action and anti-inflammatory acti...

Date: 2014   |   Origin: Oasisbr

Aquecimento ôhmico: novos desafios no tratamento térmico de materiais

Knirsch, Marcos Camargo; Santos, Carolina Alves dos; Jozala, Angela Faustino; Penna, T. C. V.; Vicente, A. A.

[Excerto] Introdução: O tratamento térmico de materiais encontra-se dentre os processos mais utilizados industrialmente. Na indústria de alimentos, por exemplo, o tratamento térmico (por possuir ação letal sobre microorganismos) é o principal procedimento físico de que a tecnologia de alimentos dispõe para aumentar a vida útil dos alimentos (Ordóñez et al., 2005). Desta forma, novos métodos de aquecimento que a...


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