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Docosanoids promote neurogenesis and angiogenesis, blood-brain barrier integrit...
Belayev, Ludmila; Hong, Sung-Ha; Menghani, Hemant; Marcell, Shawn J.; Obenaus, Andre; Freitas, Raul S.; Khoutorova, Larissa; Balaszczuk, VeronicaDocosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo) and treated with DHA (5 mg/kg, IV) or NPD1 (5 μg/per rat, ICV) and vehicles 1 h after. Neuro-behavioral assessments was conducted on days 1, 2, and 3, and on week 1, 2, 3, or 4. BrdU was injected on days...
Date: 2018
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Origin: Oasisbr