26 documents found, page 1 of 3
Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired O...
Pölkki, Anssi; Reinikainen, Matti; Rochwerg, Bram; Jung, Christian; Sendagire, Cornelius; Chaudhuri, Dipayan; Martin, Greg S.; Selander, TuomasPublisher Copyright: © 2025 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.; BACKGROUND: The ratio of arterial oxygen partial pressure to fraction of inspired oxygen (PaO2/FiO2, hereafter P/F ratio) is a key component of the Sequential Organ Failure Assessment (SOFA) score. It reflects the severity of hypoxaemic r...
Prognosis of Nonagenarian ICU Patients A Bayesian analysis of prospective Europ...
Dankl, Daniel; Bruno, Raphael Romano; Beil, Michael; Flaatten, Hans; Kelm, Malte; Sigal, Sviri; Szczeklik, Wojciech; Elhadi, MuhammedPublisher Copyright: © The Author(s) 2025.; Background: As the population ages, the number of very elderly patients (≥ 90 years, nonagenarians) admitted to intensive care units (ICUs) is increasing. This trend raises concerns about the appropriateness of ICU care for this age group, especially due to the uncertainty surrounding their prognosis. Some studies suggest that elderly ICU patients have outcomes simila...
Rationale and Methodological Approach Underlying the Development of the Sequent...
Moreno, Rui; Rhodes, Andrew; Ranzani, Otavio; Salluh, Jorge; Berger-Estilita, Joana; Coopersmith, Craig M.; Juffermans, Nicole P.; Laffey, JohnImportance: The Sequential Organ Failure Assessment (SOFA) score was published in 1996 to describe organ dysfunction in critically ill adult patients in a readily quantifiable and sequential manner. Considerable changes have occurred over the last 3 decades in the use of organ support drugs and devices and in patient outcomes, necessitating revision of the score. Objectives: To develop definitions of organ dysf...
The association of premorbid conditions with 6-month mortality in acutely admit...
de Lange, Dylan W; Soliman, Ivo W; Leaver, Susannah; Boumendil, Ariane; Haas, Lenneke E M; Watson, Ximena; Boulanger, Carol; Szczeklik, Wojciech© 2024. The Author(s).; BACKGROUND: Premorbid conditions influence the outcome of acutely ill adult patients aged 80 years and over who are admitted to the ICU. The aim of this study was to determine the influence of such premorbid conditions on 6 month survival. METHODS: Prospective cohort study in 242 ICUs from 22 countries including patients 80 years or above, admitted over a 6 months period to an ICU betwee...
Validity of the total SOFA score in patients ≥ 80 years old acutely admitted to...
Polok, Kamil; Fronczek, Jakub; Putowski, Zbigniew; Czok, Marcelina; Guidet, Bertrand; Jung, Christian; de Lange, Dylan; Leaver, Susannah; Moreno, RuiBACKGROUND: Little is known about the performance of the Sequential Organ Failure Assessment (SOFA) score in older critically ill adults. We aimed to evaluate the prognostic impact of physiological disturbances in the six organ systems included in the SOFA score. METHODS: We analysed previously collected data from a prospective cohort study conducted between 2018 and 2019 in 22 countries. Consecutive patients ≥...
The Sequential Organ Failure Assessment (SOFA) Score
Moreno, Rui; Rhodes, Andrew; Piquilloud, Lise; Hernandez, Glenn; Takala, Jukka; Gershengorn, Hayley B.; Tavares, Miguel; Coopersmith, Craig M.Funding Information: RM has no competing interest to declare relevant to this article. AR has no competing interest to declare relevant to this article. LP has no competing interest to declare relevant to this article. GH has no competing interest to declare relevant to this article. JT has no competing interest to declare relevant to this article. HBG received funding from Gilead Sciences, Inc. to serve on COV...
Frailty’s influence on 30-day mortality in old critically ill ICU patients
Wernly, Bernhard; Bruno, Raphael Romano; Beil, Michael; Flaatten, Hans; Kelm, Malte; Sigal, Sviri; Szczeklik, Wojciech; Elhadi, MuhammedFunding Information: We acknowledge all members of the VIP community. Publisher Copyright: © 2023, The Author(s).; Introduction: Frailty is widely acknowledged as influencing health outcomes among critically ill old patients. Yet, the traditional understanding of its impact has predominantly been through frequentist statistics. We endeavored to explore this association using Bayesian statistics aiming to provid...
Reporting SOFA in research
Putowski, Zbigniew; Czok, Marcelina; Polok, Kamil; Guidet, Bertrand; Jung, Christian; Bruno, Raphael Romano; de Lange, Dylan; Leaver, SusannahPublisher Copyright: © 2023 Via Medica. All rights reserved.; Background: The Sequential Organ Failure Assessment (SOFA) score is the sum of 6 components, each representing one organ system with dysfunction classified on a 4-point scale. In research, usually by default, the total SOFA score is taken into account, but it may not reflect the severity of the condition of the individual organs. Often, these values ...
In reply
Wolff, Georg; Wernly, Bernhard; Flaatten, Hans; Fjølner, Jesper; Bruno, Raphael Romano; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.
Outcomes of patients aged ≥80 years with respiratory failure initially treated ...
Polok, Kamil; Fronczek, Jakub; Guidet, Bertrand; Artigas, Antonio; De Lange, Dylan W.; Fjølner, Jesper; Leaver, Susannah; Beil, Michael; Sviri, SigalBackground: Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and during the COVID-19 pandemic. Methods: We analysed a merged cohort of older adults admitted to intensive care units (ICUs) due to respiratory failure. Patients were enrolled into one of two pr...