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Helicobacter pylori chronic infection and mucosal inflammation switches the hum...

Magalhães, A; Marcos-Pinto, R; Nairn, A; dela Rosa, M; Ferreira, RM; Junqueira-Neto, S; Freitas, DP; Gomes, J; Oliveira, P; Santos, M; Marcos, N

Helicobacter pylori exploits host glycoconjugates to colonize the gastric niche. Infection can persist for decades promoting chronic inflammation, and in a subset of individuals lesions can silently progress to cancer. This study shows that H. pylori chronic infection and gastric tissue inflammation result in a remodeling of the gastric glycophenotype with increased expression of sialyl-Lewis a/x antigens due t...

Date: 2015   |   Origin: Repositório Aberto da Universidade do Porto
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