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Pessaries containing Nanostructured Lipid Carriers (NLC) for prolonged vaginal ...

Correia, A.; Costa, C.P.; Silva, V.; Silva, R.; Lobo, J.M. Sousa; Silva, Ana Catarina

Progesterone (PRG) plays a crucial role in the female reproductive system, being the vaginal route the most adequate for its administration, as this drug has an extensive hepatic first pass effect. Nonetheless, vaginal PRG dosage forms originate immediate drug release and requires repeated administrations, which is unpleasant. Thereby, it is necessary to develop alternative delivery systems for prolonged vagina...


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