11 documents found, page 1 of 2
Nano-armed Limosilactobacillus reuteri for enhanced photo-immunotherapy and mic...
Xu, Haiting; Wang, Yajun; Liu, Ga; Zhu, Zhenhua; Shahbazi, Mohammad-Ali; Reis, R. L.; Kundu, Subhas C; Shi, Xiaoxiao; Zu, Menghang; Xiao, BoDespite being a groundbreaking approach to treating colorectal cancer (CRC), the efficacy of immunotherapy is significantly compromised by the immunosuppressive tumor microenvironment and dysbiotic intestinal microbiota. Here, leveraging the superior carrying capacity and innate immunity-stimulating property of living bacteria, a nanomedicine-engineered bacterium, LR-S-CD/CpG@LNP, with optical responsiveness, i...
Oral oncolytic magnetotactic bacteria elicit anti-colorectal tumor immunity and...
Jiang, Aodi; Li, Baoyi; Zu, Menghang; Chen, Li; Zhao, Chan; Tian, Jiesheng; Reis, R. L.; Kundu, Subhas C; Xiao, Bo; Shi, XiaoxiaoTherapeutic outcomes of colorectal cancer (CRC) are influenced by intestinal microbiota and metabolites. To leverage the tumor-tropism and microbiota-regulating properties of bacteria, we developed oncolytic magnetotactic bacteria (MSR-CPT/APPs) loaded with camptothecin (CPT) and anti-PD-L1 peptide (APP) for targeted chemo-magnetothermal immunotherapy of CRC. To further achieve oral delivery, MSR-CPT/APPs were ...
Advancements of nanoscale drug formulations for combination treatment of colore...
Li, Liqi; Chen, Maohua; Reis, R. L.; Kundu, Subhas C; Xiao, Bo; Shi, XiaoxiaoCombination chemotherapy is widely utilized in treating colorectal cancer (CRC), particularly for patients who are ineligible for surgery or those with metastatic CRC (mCRC). While this therapeutic method has demonstrated efficacy in managing CRC and mCRC, its broader clinical application is limited due to the unique physical properties, mechanisms of action, and pharmacokinetics of different chemotherapeutic d...
Transient mild photothermia improves therapeutic performance of oral nanomedici...
Ma, Ya; Gou, Shuangquan; Zhu, Zhenhua; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Si,Tieyan; Xu, Cheng; Ru, Jinlong; Shi, Xiaoxiao; Reis, R. L.The treatment outcomes of oral medications against ulcerative colitis (UC) have long been restricted by low drug accumulation in the colitis mucosa and subsequent unsatisfactory therapeutic efficacy. Here, high-performance pluronic F127 (P127)-modified gold shell (AuS)-polymeric core nanotherapeutics loading with curcumin (CUR) is constructed. Under near-infrared irradiation, the resultant P127-AuS@CURs generat...
Oral exosome-like nanovesicles from Phellinus linteus suppress metastatic hepat...
Zu, Menghang; Liu, Ga; Chen, Nanxi; Chen, Li; Gao, Qiang; Reis, R. L.; Kundu, Subhas C; Jin, Meilan; Xiao, Bo; Shi, XiaoxiaoThe biomedical application of nanotechnology in cancer treatment has demonstrated significant potential for improving treatment efficiencies and ameliorating adverse effects. However, the medical translation of nanotechnology-based nanomedicines faces challenges including hazardous environmental effects, difficulties in large-scale production, and possible excessive costs. In the present study, we extracted and...
Gas-propelled nanomotors alleviate colitis through the regulation of intestinal...
Xiao, Bo; Liang, Yuqi; Liu, Ga; Wang, Lingshuang; Zhang, Zhan; Qiu, Libin; Xu, Haiting; Carr, Sean; Shi, Xiaoxiao; Reis, R. L.; Kundu, Subhas CThe progression of ulcerative colitis (UC) is associated with immunologic derangement, intestinal hemorrhage, and microbiota imbalance. While traditional medications mainly focus on mitigating inflammation, it remains challenging to address multiple symptoms. Here, a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO2Â nanospheres with Cu2O nanoblocks. The resulting CaO2â Cu...
Mulberry leaf lipid nanoparticles: a naturally targeted CRISPR/Cas9 oral delive...
Ma, Lingli; Ma, Ya; Gao, Qiang; Liu, Shengsheng; Zhu, Zhenhua; Shi, Xiaoxiao; Dai, Fangyin; Reis, R. L.; Kundu, Subhas C; Cai, Kaiyong; Xiao, BoOral treatment of colon diseases with the CRISPR/Cas9 system has been hampered by the lack of a safe and efficient delivery platform. Overexpressed CD98 plays a crucial role in the progression of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC). In this study, lipid nanoparticles (LNPs) derived from mulberry leaves are functionalized with Pluronic copolymers and optimized to deliver the CR...
Extracellular vesicles from nanomedicine-trained intestinal microbiota substitu...
Zu, Menghang; Liu, Ga; Xu, Haiting; Zhu, Zhenhua; Zhen, Junfeng; Shi, Baoyi; Shahbazi, Mohammad-Ali; Reis, R. L.; Kundu, Subhas C; Nie, GuangjunThe biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut microbiota secrete abundant extracellular vesicles (Gm-EVs), which play a critical role in bacteria-to-bacteria and bacteria-to-host communications. Herein, intestinal microbiota are trained using tea leaf lipid/pluronic F127-coated curcumin nanocrystals (CN@Lp127s),...
Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer th...
Li, Baoyi; Zu, Menghang; Jiang, Aodi; Cao, Yingui; Wu, Jainxue; Shahbazi, Mohammad Ali; Shi, Xiaoxiao; Reis, R. L.; Kundu, Subhas C; Xiao, BoThe therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is restricted by inadequate drug accumulation, immunosuppressive microenvironment, and intestinal microbiota imbalance. To overcome these challenges, we elaborately constructed 6-gingerol (Gin)-loaded magnetic mesoporous silicon nanoparticles and functionalized their surface with mulberry leaf-extracted lipids (MLLs) and Pluronic ...
Mulberry biomass-derived nanomedicines mitigate colitis through improved inflam...
Yang, Wenjing; Ma, Ya; Xu, Haiting; Zhu, Zhenhua; Wu, Jiaxue; Xu, Cheng; Sun, Wei; Zhao, Erhu; Wang, Min; Reis, R. L.; Kundu, Subhas C; Shi, XiaoxiaoThe therapeutic outcomes of conventional oral medications against ulcerative colitis (UC) are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment. Herein, a fluorinated pluronic (FP127) was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles (MLNs) loading with resveratrol nanocrystals (RNs). The o...