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Abnormal phenotypic distribution of regulatory and effector T cells in octogena...

Cruvinel,Wilson de Melo; Mesquita Júnior,Danilo; Araújo,Júlio Antônio Pereira; Samazi,Karina Carvalho; Kállas,Esper Georges; Cendoroglo,Maysa Seabra

SummaryIntroduction:aging is associated with several immunologic changes. Regulatory (Treg) and effector T cells are involved in the pathogenesis of infectious, neoplastic, and autoimmune diseases. Little is known about the effects of aging on the frequency and function of these T cell subpopulations.Methods:peripheral blood mononuclear cells (PBMC) were obtained from 26 young (under 44 years old) and 18 elderl...

Date: 2015   |   Origin: Oasisbr
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Células T regulatórias naturais (T REGS) em doenças reumáticas

Cruvinel,Wilson de Melo; Mesquita Jr.,Danilo; Araújo,Júlio Antônio Pereira; Salmazi,Karina Carvalho; Kállas,Esper Georges; Andrade,Luis Eduardo Coelho

O sistema imune sadio deve manter o balanço entre a capacidade de responder a agentes infecciosos e de sustentar a autotolerância. A ausência de resposta adequada submete o indivíduo aos efeitos deletérios da invasão por patógenos, ao passo que o sistema respondendo de modo exacerbado pode gerar respostas inflamatórias prejudiciais. Acreditava-se que os mecanismos de deleção clonal e anergia fossem os mecanismo...

Date: 2008   |   Origin: Oasisbr
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