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Model-guided development of an evolutionarily stable yeast chassis

Pereira, Filipa; Lopes, Hélder; Maia, Paulo; Meyer, Britta; Nocon, Justyna; Jouhten, Paula; Konstantinidis, Dimitrios; Kafkia, Eleni; Rocha, Miguel

Abstract First-principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations. Yet, the theory of model-based chassis design has rarely been put to rigorous experimental test. Here, we report the development of Saccharomyces cerevisiae chassis strains for dicarboxylic acid production using genome-scale metabolic modelling. Th...

Date: 2021   |   Origin: RepositóriUM - Universidade do Minho
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Yeast chassis design for dicarboxylic acids production

Pereira, Filipa; Lopes, Helder; Maia, Paulo; Meyer, Britta; Konstantinidis, Dimitrios; Kafkia, Eleni; Kötter, Peter; Rocha, I.; Patil, Kiran R.

Date: 2018   |   Origin: RepositóriUM - Universidade do Minho
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