2 documents found, page 1 of 1
Human Cytomegalovirus vMIA Inhibits MAVS Oligomerization at Peroxisomes in an M...
Ferreira, Ana Rita; Gouveia, Ana; Magalhães, Ana Cristina; Valença, Isabel; Marques, Mariana; Kagan, Jonathan C; Ribeiro, DanielaUpon intracellular recognition of viral RNA, RIG-I-like proteins interact with MAVS at peroxisomes and mitochondria, inducing its oligomerization and the downstream production of direct antiviral effectors. The human cytomegalovirus (HCMV) is able to specifically evade this antiviral response, via its antiapoptotic protein vMIA. Besides suppressing the programmed cell death of infected cells, vMIA inhibits the ...
Emerging roles of peroxisomes in viral infections
Ferreira, Ana Rita; Marques, Mariana; Ramos, Bruno; Kagan, Jonathan C; Ribeiro, DanielaPeroxisomes, essential subcellular organelles that fulfill important functions in lipid and reactive oxygen species metabolism, have recently emerged as key players during viral infections. Their importance for the establishment of the cellular antiviral response has been highlighted by numerous reports of specific evasion of peroxisome-dependent signaling by different viruses. Recent data demonstrate that pero...