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Controversial issues in the management of hyperprolactinemia and prolactinomas ...

Vilar, Lucio; Abucham, Julio; Albuquerque, José Luciano; Araujo, Luiz Antônio; Azevedo, Monalisa F.; Boguszewski, Cesar Luiz; Casulari, Luiz Augusto

Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction,...

Data: 2019   |   Origem: Oasisbr

A review of Cushing's disease treatment by the Department of Neuroendocrinology...

Machado, Márcio Carlos; Fragoso, Maria Candida Barisson Vilares; Moreira, Ayrton Custódio; Boguszewski, César Luiz; Vieira Neto, Leonardo

The treatment objectives for a patient with Cushing's disease (CD) are remission of hypercortisolism, adequate management of co-morbidities, restoration of the hypothalamic-pituitary-adrenal axis, preservation of fertility and pituitary function, and improvement of visual defects in cases of macroadenomas with suprasellar extension. Transsphenoidal pituitary surgery is the main treatment option for the majority...

Data: 2019   |   Origem: Oasisbr

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