7 documents found, page 1 of 1
Chemical diversity and antileishmanial activity of crude extracts of Laurencia ...
Machado,Fernanda L. da S.; Lima,Wallace P.; Duarte,Heitor M.; Rossi-Bergmann,Bartira; Gestinari,Lísia M.; Fujii,Mutue T.; Kaiser,Carlos R.Chemical profiles of extracts of four species from Laurencia complex (Ceramiales, Rhodophyta) from different populations collected along Southeast Brazilian coast were assessed by High Performance Liquid Chromatography coupled with a Diode Array Detector in order to observe geographic chemical variability. Aiming to evaluate the impact of chemical diversity on potential pharmaceutical uses, the extracts were te...
Experimental and NMR theoretical methodology applied to geometric analysis of t...
Soares,Breno Almeida; Firme,Caio Lima; Maciel,Maria Aparecida Medeiros; Kaiser,Carlos R.; Schilling,Eduardo; Bortoluzzi,Adailton J.trans-Dehydrocrotonin (t-DCTN) a bioactive 19-nor-diterpenoid clerodane type isolated from Croton cajucara Benth, is one of the most investigated clerodane in the current literature. In this work, a new approach joining X-ray diffraction data, nuclear magnetic resonance (NMR) data and theoretical calculations was applied to the thorough characterization of t-DCTN. For that, the geometry of t-DCTN was reevaluate...
Atividade biológica de metabólitos secundários de algas marinhas do gênero Laur...
Machado,Fernanda L. da S.; Kaiser,Carlos R.; Costa,Sônia S.; Gestinari,Lísia M.; Soares,Angélica R.As algas vermelhas do gênero Laurencia são conhecidas como uma riquíssima fonte de metabólitos secundários. As principais classes químicas já isoladas são terpenos - sesquiterpenos, diterpenos, triterpenos - e acetogeninas. Estudos apontam que estas substâncias apresentam importantes atividades biológicas, principalmente citotóxica e antibacteriana. Existem ainda alguns poucos trabalhos com informações sobre at...
Synthesis of α- and β-lapachone derivatives from hetero diels-alder trapping of...
Silva,Fernando de C. da; Ferreira,Sabrina B.; Kaiser,Carlos R.; Pinto,Angelo C.; Ferreira,Vitor F.Methylene and aryl o-quinone methides (o-QMs) generated by Knoevenagel condensation of 2-hydroxy-1,4-naphthoquinone with formaldehyde and arylaldehydes, undergo facile hetero Diels-Alder reaction with some substituted styrenes (as dienophiles) in aqueous ethanol media providing derivatives of α- and β-lapachone.
Natural and semi-synthetic clerodanes of Croton cajucara and their cytotoxic ef...
Maciel,Maria Aparecida M.; Martins,Jenilce R.; Pinto,Angelo C.; Kaiser,Carlos R.; Esteves-Souza,Andressa; Echevarria,AureaThe clerodane-type diterpene, trans-dehydrocrotonin (1) the major component of Croton cajucara has shown striking correlation with its therapeutic use in traditional folk medicine. Phytochemical investigations led to the isolation of the metabolites 1, cajucarinolide (6), isocajucarinolide (7), trans-crotonin (2), trans-cajucarin B (3), cis-cajucarin B (4), trans-cajucarin A (5), N-methyltyrosine, vanillic acid...
Chemical composition and anti-inflammatory activity of the hydrodistillate from...
Siani,Antonio C.; Silva,Ana M. P.; Nakamura,Marcos J.; De Carvalho,Márcia V.; Henriques,Maria G. M. O.; Ramos,Mônica F. S.; Kaiser,Carlos R.A mixture of the benzofuran remirol and the benzopyran isoevodionol (5.7:1) was extracted by hydrodistillation from rhizomes of Mariscus pedunculatus. They were purified by successive thin layer chromatography. Their structure elucidation were confirmed by 2D-NMR experiments. The structure of remirol was also confirmed by its hydrogenation product. Crude distillate and the pure compounds were screened for anti-...
RMN 2D: Detecção inversa e gradiente de campo na determinação estrutural de com...
Kaiser,Carlos R.A view of the general aspects involving the 2D NMR spectroscopy using inverse detection and field gradient techniques is presented through the analysis of a sesquiterpene.