5 documents found, page 1 of 1
A multinational Delphi consensus to end the COVID-19 public health threat
COVID-19 Consensus Statement Panel; Lazarus, Jeffrey V.; Romero, Diana; Kopka, Christopher J.; Karim, Salim Abdool; Abu-Raddad, Laith J.Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic1,2. Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific...
Morbidity, mortality, and long-term consequences associated with diarrhoea from...
Khalil, Ibrahim A.; Troeger, Christopher; Rao, Puja C.; Blacker, Brigette F.; Brown, Alexandria; Brewer, Thomas G.; Colombara, Danny V.Background The protozoan Cryptosporidium is a leading cause of diarrhoea morbidity and mortality in children younger than 5 years. However , the true global burden of C ryptosporidium infection in children younger than 5 years might have been underestimated in previous quantifications because it only took account of the acute eects of diarrhoea. W e aimed to demonstrate whether there is a causal relation betwee...
Use of antibiotics in children younger than two years in eight countries : a pr...
Rogawski, Elizabeth T.; Platts-Mills, James A.; Seidman, Jessica C.; John, Sushil; Mahfuz, Mustafa; Ulak, Manjeswori; Shrestha, Sanjaya K.Objective To describe the frequency and factors associated with antibiotic use in early childhood, and estimate the proportion of diarrhoea and respiratory illnesses episodes treated with antibiotics. Methods Between 2009 and 2014, we followed 2134 children from eight sites in Bangladesh, Brazil, India, Nepal, Pakistan, Peru, South Africa and the United Republic of Tanzania, enrolled in the MAL-ED birth cohort ...
Causal pathways from enteropathogens to environmental enteropathy : findings fr...
Kosek, Margaret N.; Ahmed, Tahmeed; Bhutta, Zulfiquar; Caulfield, Laura; Guerrant, Richard; Houpt, Eric; Kang, Gagandeep; Lee, Gwenyth; Lima, AldoBackground: Environmentalenteropathy (EE),the adverseimpact offrequent and numerous entericinfections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populations. A theory-driven systems model to critically evaluate pathways through which enteropathogens, gut permeability, and...
Fecal markers of intestinal inflammation and permeability associated with the s...
Kosek, Rashidul; Babji, Sudhir; Shrestha, Sanjaya; Qureshi, Shahida; Amidou, Samie; Mduma, Estomih; Lee, Gwenyth; Yori, Pablo PeñataroEnteric infections are associated with linear growth failure in children. To quantify the association between intestinal inflammation and linear growth failure three commercially available enzyme-linked immunosorbent assays (neopterin [NEO], alpha-anti-trypsin [AAT], and myeloperoxidase [MPO]) were performed in a structured sampling of asymptomatic stool from children under longitudinal surveillance for diarrhe...