32 documents found, page 1 of 4
Neuroprogression in post-traumatic stress disorder: a systematic review
Antonelli-Salgado,Thyago; Ramos-Lima,Luis Francisco; Machado,Cristiane dos Santos; Cassidy,Ryan Michael; Cardoso,Taiane de Azevedo; Kapczinski,FlávioAbstract Introduction Neuroprogression has been proposed as the pathological rewiring of the brain that takes place in parallel with clinical and neurocognitive deterioration in the course of psychiatric disorders. This study aims to review the biological underpinnings and clinical outcomes related to neuroprogression in post-traumatic stress disorder (PTSD). Methods We performed a systematic review by searchin...
Differentiating irritable mood and disruptive behavior in adults
Knackfuss,Ana Cláudia U.; Leibenluft,Ellen; Brotman,Melissa A.; de Moura Silveira Júnior,Érico; Simioni,André; Teixeira,Lorenna S.; Gerchmann,LucianaAbstract Introduction Irritability has both mood and behavioral manifestations. These frequently co-occur, and it is unclear to what extent they are dissociable domains. We used confirmatory factor analysis and external validators to investigate the independence of mood and behavioral components of irritability. Methods The sample comprised 246 patients (mean age 45 years; 63% female) from four outpatient progr...
Cardiovascular risk and bipolar disorder: factors associated with a positive co...
Wageck,Aline R.; Torres,Felipe S.; Gama,Clarissa S.; Martins,Dayane S.; Scotton,Ellen; Reckziegel,Ramiro; Costanzi,Monise; Rosa,Regis G.Objective: Cardiovascular disease is the leading cause of death in patients with bipolar disorder. The aim of this study was to evaluate the factors associated with positive coronary calcium score (CCS) in individuals with bipolar disorder type 1. Methods: Patients from the Bipolar Disorder Program at Hospital de Clínicas de Porto Alegre, Brazil, underwent computed tomography scanning for calcium score measurem...
Cell therapy in the treatment of bipolar mania in an animal model: a proof of c...
Ascoli,Bruna M.; Colombo,Rafael; Géa,Luiza P.; Terraciano,Paula B.; Pizzato,Sabrina B.; de Oliveira,Fernanda S.; Cirne-Lima,Elizabeth; Kapczinski,FlávioAbstract Introduction The rationale of mesenchymal stem cells (MSCs) as a novel therapeutic approach in certain neurodegenerative diseases is based on their ability to promote neurogenesis. Hippocampal atrophy has been related to bipolar disorder (BD) in preclinical, imaging and postmortem studies. Therefore, the development of new strategies to stimulate the neurogenesis process in BD is crucial. Objectives To...
Virginia Woolf, neuroprogression, and bipolar disorder
Boeira,Manuela V.; Berni,Gabriela de Á.; Passos,Ives C.; Kauer-Sant’Anna,Márcia; Kapczinski,FlávioFamily history and traumatic experiences are factors linked to bipolar disorder. It is known that the lifetime risk of bipolar disorder in relatives of a bipolar proband are 5-10% for first degree relatives and 40-70% for monozygotic co-twins. It is also known that patients with early childhood trauma present earlier onset of bipolar disorder, increased number of manic episodes, and more suicide attempts. We ha...
Frequency of brain tissue donation for research after suicide
Longaray,Vanessa K.; Padoan,Carolina S.; Goi,Pedro D.; da Fonseca,Rodrigo C.; Vieira,Daniel C.; Oliveira,Francine H. de; Kapczinski,FlávioObjectives: To describe the frequency of brain tissue donation for research purposes by families of individuals that committed suicide. Methods: All requests for brain tissue donation to a brain biorepository made to the families of individuals aged 18-60 years who had committed suicide between March 2014 and February 2016 were included. Cases presenting with brain damage due to acute trauma were excluded. Resu...
Psychiatric and clinical correlates of rapid cycling bipolar disorder: a cross-...
Gigante,Alexandre D.; Barenboim,Ivan Y.; Dias,Rodrigo da S.; Toniolo,Ricardo A.; Mendonça,Tiago; Miranda-Scippa,Ângela; Kapczinski,Flávio; Lafer,BenyObjective: Rapid cycling (RC) is a feature of bipolar disorder (BD) that has been associated with worse outcome and more severe disability. Our goal was to investigate the association of demographic and clinical factors with RC. Methods: We compared RC and non-rapid cycling (NRC) BD patients from the Brazilian Research Network in Bipolar Disorder (BRN-BD) regarding age at onset of BD; total number of episodes; ...
Shortened telomere length in bipolar disorder: a comparison of the early and la...
Barbé-Tuana,Florencia M.; Parisi,Mariana M.; Panizzutti,Bruna S.; Fries,Gabriel R.; Grun,Lucas K.; Guma,Fátima T.; Kapczinski,Flávio; Berk,MichaelObjective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among partic...
Ethanol during adolescence decreased the BDNF levels in the hippocampus in adul...
Scheidt,Letícia; Fries,Gabriel Rodrigo; Stertz,Laura; Cabral,João Carlos Centurion; Kapczinski,Flávio; Almeida,Rosa Maria Martins deObjective:To investigate the effects of ethanol exposure in adolescent rats during adulthood by assesssing aggression and anxiety-like behaviors and measuring the levels of inflammatory markers.Methods:Groups of male Wistar rats (mean weight 81.4 g, n = 36) were housed in groups of four until postnatal day (PND) 60. From PNDs 30 to 46, rats received one of three treatments: 3 g/kg of ethanol (15% w/v, orally, n...
Association of serum brain-derived neurotrophic factor (BDNF) and tumor necrosi...
Brum,Cristiano; Stertz,Laura; Borba,Ericksen; Rumi,Danielle; Kapczinski,Flávio; Camozzato,AnaluizaObjective: To evaluate brain-derived neurotrophic factor (BDNF) and tumor necrosis factor-α (TNF-α) blood levels as disease biomarkers of delirium in oncology inpatients. Methods: Seventeen oncology inpatients with delirium, 28 oncology inpatients without delirium, and 25 non-oncology controls (caregivers) were consecutively recruited from a Brazilian cancer center. This sample was matched by age, sex, and educ...