Made available in DSpace on 2018-11-26T16:48:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-07-20; Science and Technology Facilities Council; UK Space Agency; ICREA; A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the na...
Made available in DSpace on 2018-11-26T16:56:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-07-01; United States National Science Foundation (NSF); Science and Technology Facilities Council (STFC) of the United Kingdom; Max-Planck Society; State of Niedersachsen/Germany; Australian Research Council; Netherlands Organisation for Scientific Research; EGO consortium; Council of Scientific and Industrial...
Surgical site infections (SSI) represent a serious health problem that occur after invasive surgery, thus new antimicrobial biomaterials able to prevent SSI are needed. Silks are natural biopolymers with excellent biocompatibility, low immunogenicity and controllable biodegradability. Spider silkbased materials can be bioengineered and functionalized with specific peptides, such as antimicrobial peptides, creat...
The objective of this work was to exploit the fibronectin type II (FNII) module from human matrix metalloproteinase-2 as a functional domain for the development of silk-based biopolymer blends that display enhanced cell adhesion properties. The DNA sequence of spider dragline silk protein (6mer) was genetically fused with the FNII coding sequence and expressed in Escherichia coli. The chimeric protein 6mer + FN...
The successful treatment of bone infections is a major challenge in the field of orthopedics. There are some common methods for treating bone infections, including systemic antibiotic administration, local nondegradable drug vehicles, and surgical debridement, and each of these approaches has advantages and disadvantages. In the present study, the antibiotic vancomycin (VANCO) was loaded in silk fibroin nanopar...
[Excerpt] The impressive mechanical properties, along with established biocompatibility and slow degradability, render silk as an interesting biomaterial for bone tissue engineering applications. New silk-based scaffolds resembling bone lamellar structure were successfully developed using a freeze-drying technique. The structure could be controlled directly by the solute concentration and freezing parameters. T...