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The global burden of childhood and adolescent cancer in 2017: an analysis of th...

Force, LM; Abdollahpour, I; Advani, SM; Agius, D; Ahmadian, E; Alahdab, F; Alam, T; Alebel, A; Alipour, V; Allen, CA; Almasi-Hashiani, A; Alvarez, EM

Background Accurate childhood cancer burden data are crucial for resource planning and health policy prioritisation. Model-based estimates are necessary because cancer surveillance data are scarce or non-existent in many countries. Although global incidence and mortality estimates are available, there are no previous analyses of the global burden of childhood cancer represented in disability-adjusted life-years...


Global, regional, and national age-sex-specific mortality for 282 causes of dea...

Roth, GA; Abate, D; Abate, KH; Abay, SM; Abbafati, C; Abbasi, N; Abbastabar, H; Abd-Allah, L; Abdela, J; Abdelalim, A; Abdollahpour, I; Abdulkader, RS

Background Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly availa...


Burden of cancer in the Eastern Mediterranean Region, 2005–2015: findings from ...

Alsharif, U; El Bcheraoui, C; Khalil, I; Charara, R; Moradi-Lakeh, M; Afshin, A; Collison, M; Chew, A; Krohn, K; Daoud, F; Dicker, D; Foreman, K

Objectives: To estimate incidence, mortality, and disability-adjusted life years (DALYs) caused by cancer in the Eastern Mediterranean Region (EMR) between 2005 and 2015. Methods: Vital registration system and cancer registry data from the EMR region were analyzed for 29 cancer groups in 22 EMR countries using the Global Burden of Disease Study 2015 methodology. Results: In 2015, cancer was responsible for 9.4%...


Trends in HIV/AIDS morbidity and mortality in Eastern Mediterranean countries, ...

El Bcheraoui, C; Wang, H; Charara, R; Khalil, I; Moradi-Lakeh, M; Afshin, A; Collison, M; Daoud, F; Chew, A; Krohn, K; Carter, A; Foreman, K; He, F

Objectives: We used the results of the Global Burden of Disease 2015 study to estimate trends of HIV/AIDS burden in Eastern Mediterranean Region (EMR) countries between 1990 and 2015. Methods: Tailored estimation methods were used to produce final estimates of mortality. Years of life lost (YLLs) were calculated by multiplying the mortality rate by population by age-specific life expectancy. Years lived with di...


Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost,...

Fitzmaurice, C; Akinyemiju, T; Al Lami, F; Alam, T; Alizadeh-Navaei, R; Allen, C; Alsharif, U; Alvis-Guzman, N; Amini, E; Anderson, B; Aremu, O

Importance: The increasing burden due to cancer and other noncommunicable diseases poses a threat to human development, which has resulted in global political commitments reflected in the Sustainable Development Goals as well as the World Health Organization (WHO) Global Action Plan on Non-Communicable Diseases. To determine if these commitments have resulted in improved cancer control, quantitative assessments...


Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-ba...

Zhou, B; Lu, Y; Hajifathalian, K; Bentham, J; Di Cesare, M; Danaei, G; Bixby, H; Cowan, MJ; Ali, MK; Taddei, C.; Lo, WC; Ninomiya, T; Noale, M; Noto, D

Background One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with diabetes. Method...


Effects of diabetes definition on global surveillance of diabetes prevalence an...

Danaei, G; Fahimi, S; Lu, Y; Zhou, B; Hajifathalian, K; Di Cesare, M; Lo, WC; Reis-Santos, B; Cowan, MJ; Shaw, JE; Bentham, J; Mohammad, K; Mohan, V

Background Diabetes has been defi ned on the basis of diff erent biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the eff ect of diff erent diagnostic defi nitions on both the population prevalence of diabetes and the classifi cation of previously undiagnosed individuals as having diabetes versus not having diabetes in a po...


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