8 documents found, page 1 of 1
Viral metagenomics performed in patients with acute febrile syndrome during Tox...
Bezerra,Rafael dos Santos; Diefenbach,Cristiane Fração; Pereira,Dalnei Veiga; Kashima,Simone; Slavov,Svetoslav NanevABSTRACT Toxoplasmosis is a zoonotic infection caused by the protozoan parasite Toxoplasma gondii. The infection is widely disseminated in the human population and is usually benign or asymptomatic. Systemic T. gondii infection presents risks for pregnant women and AIDS patients. Although rare, T. gondii can cause outbreaks in urban centers. The origin of these outbreaks is not completely understood but probabl...
T cell receptor signaling pathway is overexpressed in CD4 + T cells from HAM/TS...
Pinto,Mariana Tomazini; Malta,Tathiane Maistro; Rodrigues,Evandra Strazza; Takayanagui,Osvaldo Massaiti; Tanaka,Yuetsu; Covas,Dimas TadeuABSTRACT Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus related to the chronic neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4+ T cells activation appears to play a key role on HTLV-1 infection. Here we investigated the expression of genes associated to T cell activation CD3e molecule, epsilon (CD3?), lymphocyte-specific protein tyrosine kinas...
Molecular and clinical evaluation of the acute human parvovirus B19 infection: ...
Slavov,Svetoslav Nanev; Kashima,Simone; Silva-Pinto,Ana Cristina; Amarilla,Alberto Anastacio; Aquino,Victor Hugo; Covas,Dimas TadeuHuman parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease has been examined. One of them developed life-threatening condition requiring emergency transfusions, while the oth...
Distribution of QPY and RAH haplotypes of granzyme B gene in distinct Brazilian...
Garcia,Fernanda Bernadelli; Kashima,Simone; Rodrigues,Evandra Strazza; Silva,Israel Tojal; Malta,Tathiane MaistroINTRODUCTION: The cytolysis mediated by granules is one of the most important effector functions of cytotoxic T lymphocytes and natural killer cells. Recently, three single nucleotide polymorphisms (SNPs) were identified at exons 2, 3, and 5 of the granzyme B gene, resulting in a haplotype in which three amino acids of mature protein Q48P88Y245 are changed to R48A88H245, which leads to loss of cytotoxic activit...
Association between Knops blood group polymorphisms and susceptibility to malar...
Fontes,Aparecida Maria; Kashima,Simone; Bonfim-Silva,Ricardo; Azevedo,Rochele; Abraham,Kuruvilla Joseph; Albuquerque,Sérgio Roberto LopesComplement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with suscepti...
Epidemiology of HIV/HCV coinfection in patients cared for at the Tropical Medic...
Victoria,Marilú Barbieri; Victoria,Flamir da Silva; Torres,Kátia Luz; Kashima,Simone; Covas,Dimas Tadeu; Malheiro,AdrianaThe association of HIV infection and hepatitis C virus (HCV) infection often occurs because both viruses share the same transmission routes, increasing the possibility of HIV/HCV coinfection. World prevalence greater than 30% of coinfected cases is estimated, and it can reach 90% depending on the transmission route. With the aim of determining the frequency and profile of HIV/HCV coinfected patients, a descript...
Clonagem e expressão da glicoproteína transmembrana do vírus linfotrópico de cé...
Russo-Carbolante,Elisa Maria de Sousa; Penteado,Flora Cristina Lobo; Medeiros,Luciene; Kashima,Simone; Takayanagui,Oswaldo M.; Covas,Dimas TadeuO HTLV-1 é o vírus causador da leucemia/linfoma de célula T no adulto e de uma desordem neurológica conhecida por mielopatia associada ao HTLV ou paraparesia espástica tropical. Um dos modos de transmissão é pelo sangue contaminado e seus subprodutos e, devido ao risco de infecções associadas ao HTLV sua pesquisa na triagem de doadores de sangue foi introduzida no Brasil a partir de 1993. Os kits diagnósticos u...
Analysis of the p53 gene by PCR-SSCP in ten cases of Wilms tumor
Defavery,Ricardo; Lemos,José Alexandre Rodrigues; Kashima,Simone; Bernardes,José Eduardo; Scridelli,Carlos Alberto; Covas,Dimas Tadeu; Tone,Luiz GonzagaCONTEXT: Mutations of the p53 tumor suppressor gene are the most frequent alterations observed in human neoplasias affecting adults. In pediatric oncology, however, they have seldom been identified. Wilms tumor is a renal neoplasia commonly occurring in children and is associated with mutations of the WT1 gene. The correlation between Wilms tumor and alterations of the p53 gene has not been well established, ...