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Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus...

Sousa-Ferreira, Lígia; Garrido, Manuel Joaquim Marques; Nascimento-Ferreira, Isabel; Nóbrega, Clévio; Carvalho, Ana dos Santos

Neuropeptide Y (NPY) produced by arcuate nucleus (ARC) neurons has a strong orexigenic effect on target neurons. Hypothalamic NPY levels undergo wide-ranging oscillations during the circadian cycle and in response to fasting and peripheral hormones (from 0.25 to 10-fold change). The aim of the present study was to evaluate the impact of a moderate long-term modulation of NPY within the ARC neurons on food consu...


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