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In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol d...

Silva, Luiz Francisco Rocha e; Nogueira, Karla Lagos; Pinto, Ana Cristina da Silva; Katzin, Alejandro Miguel; Sussmann, Rodrigo Antonio Ceschini

4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stability and significant in vitro antiplasmodial activity. The aim of this work was to study the in vitro inhibition of hemozoin formation, inhibition of isoprenoid biosynthesis in Plasmodium falciparum cultures, and in v...

Date: 2020   |   Origin: Oasisbr


The isotype composition and avidity of naturally acquired anti-plasmodium falci...

Ferreira, Marcelo Urbano; Kimura, Emilia Akemi Shiraishi; Souza, Jos? Maria de; Katzin, Alejandro Miguel

This work was supported by grants from the UNDP/World Bank/World Health Organization Special Program for Research and Training in Tropical Diseases, the Program for Malaria Contrai in the Amazon (PCMAM) of the National Health Foundation (Brazilian Ministry of Health), and the Fundacao para o Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil.; Universidade de S?o Paulo. Instituto de Ci?ncias Biom?dicas. ...

Date: 2019   |   Origin: Oasisbr




Antimalarial activity of the terpene nerolidol

Katzin, Alejandro Miguel

Date: 2016   |   Origin: Oasisbr


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