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Immunoglobulin genes implicated in glioma risk

Pandey, Janardan P.; Kaur, Navtej; Costa, Sandra Maria Araújo da; Amorim, Júlia; Nabiço, Rui; Linhares, Paulo; Vaz, Rui; Pereira, Marta Viana

Both genetic and environmental factors are thought to be causal in gliomagenesis. Several genes have been implicated in glioma development, but the putative role of a major immunity-related gene complex member, immunoglobulin heavy chain ? (IGHG) has not been evaluated. Prior observations that IGHG-encoded ? marker (GM) allotypes exhibit differential sensitivity to an immunoevasion strategy of cytomegalovirus, ...

Date: 2014   |   Origin: RepositóriUM - Universidade do Minho
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