14 documents found, page 1 of 2
Ulcerative colitis is under dual (Mitochondrial and Nuclear) genetic control
Rosa, Alexandra; Abrantes, Patrícia; Sousa, Inês; Francisco, Vânia; Santos, Patrícia; Francisco, David; M Xavier, Joana; Oliveira, Sofia A.Background: Cellular oxidative stress and genetic susceptibility have been implicated in the multifactorial etiology of ulcerative colitis (UC). The nuclear genome association with UC has been intensely investigated, but the role of the mitochondrial DNA (mtDNA) has received far less attention and may account for part of the missing heritability. This study is a comprehensive analysis of the mtDNA contribution ...
Mitochondrial genome association study with peripheral arterial disease and ven...
Abrantes, Patrícia; Rosa, Alexandra; Francisco, Vania; Sousa, Inês; M Xavier, Joana; Oliveira, Sofia A.Background and aims: Peripheral arterial disease (PAD) and venous thromboembolism (VTE) are vascular traits sharing common modifiable and non-modifiable risk factors. These vascular pathologies have known nuclear-encoded genetic risk factors and the mitochondrial DNA may account for part of the missing heritability. To determine if PAD and VTE have a dual genetic control (mitochondrial and nuclear), we hereby i...
Ulcerative colitis is under dual (mitochondrial and nuclear) genetic control
Rosa, Alexandra; Abrantes, Patrícia; Sousa, Inês; Francisco, Vânia; Santos, Patrícia; Francisco, David; Xavier, Joana M.; Oliveira, Sofia A.Background: Cellular oxidative stress and genetic susceptibility have been implicated in the multifactorial etiology of ulcerative colitis (UC). The nuclear genome association with UC has been intensely investigated, but the role of the mitochondrial DNA (mtDNA) has received far less attention and may account for part of the missing heritability. This study is a comprehensive analysis of the mtDNA contribution ...
Mitochondrial genome association study with peripheral arterial disease and ven...
Abrantes, Patrícia; Rosa, Alexandra; Francisco, Vânia; Sousa, Inês; Xavier, Joana M.; Oliveira, Sofia A.Background and aims: Peripheral arterial disease (PAD) and venous thromboembolism (VTE) are vascular traits sharing common modifiable and non-modifiable risk factors. These vascular pathologies have known nuclear-encoded genetic risk factors and the mitochondrial DNA may account for part of the missing heritability. To determine if PAD and VTE have a dual genetic control (mitochondrial and nu clear), we hereby ...
Genetic Variants Underlying Risk of Intracranial Aneurysms: Insights from a GWA...
Abrantes, Patrícia; Santos, Maria M.; Sousa, Inês; Xavier, Joana M.; Francisco, Vânia; Krug, Tiago; Sobral, João; Matos, Mafalda; Martins, MadalenaSubarachnoid hemorrhage (SAH) is a life-threatening event that most frequently leads to severe disability and death. Its most frequent cause is the rupture of a saccular intracranial aneurysm (IA), which is a blood vessel dilation caused by disease or weakening of the vessel wall. Although the genetic contribution to IA is well established, to date no single gene has been unequivocally identified as responsible...
Gene expression profiling and association studies implicate the neuregulin sign...
Xavier, Joana M; Krug, Tiago; Davatchi, Fereydoun; Shahram, Farhad; Fonseca, Benedita V.; Jesus, Gorete; Barcelos, Filipe; Vedes, Joana; Salgado, ManuelBehçet's disease (BD) is a complex disease with genetic and environmental risk factors implicated in its etiology; however, its pathophysiology is poorly understood. To decipher BD's genetic underpinnings, we combined gene expression profiling with pathway analysis and association studies. We compared the gene expression profiles in peripheral blood mononuclear cells (PBMCs) of 15 patients and 14 matched contro...
Influence of different solvents on the morphology of the hybrid layer using two...
Ferreira, João C.; Pires, Patrícia T.; Oliveira, Sofia A.; Silva, Mário J.; Melo, Paulo R.To evaluate if different etch-and-rinse adhesive solvents influenced the hybrid layer’s morphology. Four one-bottle etch-and-rinse adhesive systems containing different solvents—Group A: Scotchbond 1XTTM– 3M ESPE, Group B: XP – BondTM – Dentsply, Group C: Prime&Bond NT1 – Dentply, and Group D: One Coat Bond1 - Colte`ne Whaledent—were applied onto 32 dentin discs which were thermocycled, prepared, and examined u...
Perspetiva histórica e conceitos atuais dos sistemas adesivos amelodentinários:...
Coelho, Ana; Canta, João P.; Martins, Jorge N. R.; Oliveira, Sofia A.; Marques, PaulaDesde Buonocore, a adesão ao esmalte permaneceu consistente ao longo de décadas. Pelo contrario, a adesão a dentina revelou-se imprevisível, levando a sucessiva modificação dos sistemas adesivos, caracteristicamente focados na necessidade de ultrapassar as dificuldades na adesão a dentina. A enorme multiplicidade de adesivos continuamente introduzidos no mercado torna difícil manter um conhecimento atualizado r...
Safe use of ozone gas in enamel adhesion
Pires, Patrícia T.; Ferreira, João C.; Oliveira, Sofia A.; Silva, Mário J.; Melo, Paulo R.Purpose: Evaluate the shear bond strength of a self-etching system to enamel pretreated with ozone and its type of fracture. Matherial and methods: Thirty sound bovine incisors were bisected and polished just before the application of the adhesive system. The adhesion area was limited to a 3-mm diameter. The specimens were randomly assigned to the experimental groups (n = 15) and composite resin cylinders were ...
Replication of the CELSR1 association with ischemic stroke in a Portuguese case...
Gouveia, Liliana O.; Sobral, João; Vicente, A.M.; Ferro, José M.; Oliveira, Sofia A.OBJECTIVES: Replication of GWAS association findings remains the gold standard for results validation. Our aim was to test the association of four polymorphisms (rs1671021 in LLGL2, rs753307 in RUVBL2, rs6007897 and rs4044210 in CELSR1) previously identified as ischemic stroke (IS) risk factors in a phased GWAS performed on 6341 Japanese individuals [1]. METHODS: These polymorphisms were genotyped in a Portugue...