4 documents found, page 1 of 1
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic mode...
Keene, CD; Rodrigues, CMP; Eich, T; Chhabra, MS; Steer, CJ; Low, WCHuntington's disease (HD) is an untreatable neurological disorder caused by selective and progressive degeneration of the caudate nucleus and putamen of the basal ganglia. Although the etiology of HD pathology is not fully understood, the observed loss of
A bile acid protects against motor and cognitive deficits and reduces striatal ...
Keene, CD; Rodrigues, CMP; Eich, T; Linehan-Stieers, C; Abt, A; Kren, BT; Steer, CJ; Low, WCThere is currently no effective treatment for Huntington's disease (HD), a progressive, fatal, neurodegenerative disorder characterized by motor and cognitive deterioration. It is well established that HD is associated with perturbation of mitochondrial e
Tauroursodeoxycholic acid prevents apoptosis induced by the neurotoxin 3-nitrop...
Rodrigues, CMP; Keene, CD; Linehan-Stieers, C; Ma, X; Low, W; Steer, CJ
Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropio...
Rodrigues, CMP; Linehan-Stieers, C; Keene, CD; Ma, XM; Kren, BT; Low, WC; Steer, CJUrsodeoxycholic acid (UDCA) has been shown to be a strong modulator of the apoptotic threshold in both hepatic and nonhepatic cells. 3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, appears to cause apoptotic neuronal ce