15 documents found, page 1 of 2
Towards a consensus definition of allostatic load: a multi-cohort, multi-system...
McCrory, C; McLoughlin, S; Layte, R; NiCheallaigh, C; O'Halloran, AM; Barros, H; Berkman, LF; Bochud, M; Crimmins, EM; Farrell, MT; Fraga, S; Grundy, EBackground: Allostatic load (AL) is a multi-system composite index for quantifying physiological dysregulation caused by life course stressors. For over 30 years, an extensive body of research has drawn on the AL framework but has been hampered by the lack of a consistent definition.Methods: This study analyses data for 67,126 individuals aged 40-111 years participating in 13 different cohort studies and 40 bio...
Adverse Childhood Events and Health Biomarkers: A Systematic Review
Soares, S; Rocha, V; Kelly-Irving, M; Stringhini, S; Fraga, SBackground: This systematic review aimed to summarize evidence reporting epigenetic and/or neuro-immuno-endocrine embedding of adverse childhood events (ACEs) in children, with a particular focus on the short-term biological effect of those experiences. Methods: A search was conducted in PsycINFO®, PubMed®, Isi Web of Knowledge and Scopus, until July 2019, to identify papers reporting the short-term biological ...
Special Report: The Biology of Inequalities in Health: The Lifepath Consortium
Vineis, P; Avendano-Pabon, M; Barros, H; Bartley, M; Carmeli, C; Carra, L; Chadeau-Hyam, M; Costa, G; Delpierre, C; D'Errico, A; Fraga, S; Giles, GFunded by the European Commission Horizon 2020 programme, the Lifepath research consortium aimed to investigate the effects of socioeconomic inequalities on the biology of healthy aging. The main research questions included the impact of inequalities on health, the role of behavioral and other risk factors, the underlying biological mechanisms, the efficacy of selected policies, and the general implications of ...
Patterning of educational attainment across inflammatory markers: Findings from...
Maurel, M; Castagné, R; Berger, E; Bochud, M; Chadeau-Hyam, M; Fraga, S; Gandini, M; Hutri-Kähönen, N; Jalkanen, S; Kivimäki, M; Marmot, M; McCrory, CBackground. Evidence suggests that the inflammatory reaction, an adaptive response triggered by a variety of harmful stimuli and conditions involved in the risk and development of many chronic diseases, is a potential pathway through which the socioeconomic environment is biologically embedded. Difficulty in interpreting the role of the inflammatory system in the embodiment dynamic arises because of heterogenei...
Childhood socioeconomic conditions are associated with increased chronic low-gr...
Fraga, S; Severo, M; Ramos, E; Kelly-Irving, M; Silva, S; Ribeiro, AI; Petrovic, D; Barros, H; Stringhini, SObjective Early life adversity has been associated with increased risk of inflammation and inflammation-related diseases in adulthood. This study aimed to examine the association of childhood socioeconomic conditions with chronic low-grade inflammation over adolescence. Methods We used information on 2942 members (1507 girls and 1435 boys) of the EPITeen (Epidemiological Health Investigation of Teenagers in Por...
The contribution of sleep to social inequalities in cardiovascular disorders: a...
Petrovic, D; Haba-Rubio, J; de Mestral, Vargas, C; Kelly-Irving, M; Vineis, P; Kivimäki, M; Nyberg, S; Gandini, M; Bochud, M; Vollenweider, PAims: Sleep disturbances exhibit a strong social patterning, and inadequate sleep has been associated with adverse health outcomes, including cardiovascular disorders (CVD). However, the contribution of sleep to socioeconomic inequalities in CVD is unclear. This study pools data from eight European cohorts to investigate the role of sleep duration in the association between life-course socioeconomic status (SES...
Neighbourhood socioeconomic deprivation and allostatic load: a multi-cohort study
Ribeiro, AI; Fraga, S; Kelly-Irving, M; Delpierre, C; Stringhini, S; Kivimaki, M; Joost, S; Guessous, I; Gandini, M; Vineis, P; Barros, HLiving in deprived neighbourhoods may have biological consequences, but few studies have assessed this empirically. We examined the association between neighbourhood deprivation and allostatic load, a biological marker of wear and tear, taking into account individual’s socioeconomic position. We analysed data from three cohort studies (CoLaus-Switzerland; EPIPorto-Portugal; Whitehall II-UK) comprising 16,364 pa...
Husbands' and wives' discordant self-reports on couple-level variables: implica...
Amorim, M; Silva, S; Severo, M; Kelly-Irving, M; Samorinha, C; Alves, EBackground: Using the couple as unit of analysis raises methodological challenges. This study aims to discuss the appropriate proxy to use in statistical analyses when couples provide discordant answers on the following couple-level variables: household monthly income and length of marital relationship. Methods: During 12 months (July 2013–June 2014), parents of very preterm infants admitted at all level III Ne...
Needs of parents of very preterm infants in Neonatal Intensive Care Units: A mi...
Amorim, M; Alves, E; Kelly-Irving, M; Silva, SObjectives To explore needs of parents of very preterm infants hospitalised in Neonatal Intensive Care Units according to their socioeconomic position, obstetric history and infant’s characteristics. Methodology Sequential explanatory mixed methods study. Individual quantitative questionnaires (n = 118 mothers; 89 fathers) during infants’ hospitalisation; couples-based semi-structured interviews (n = 26) four m...
Quality of life among parents of preterm infants: a scoping review
Amorim, M; Silva, S; Kelly-Irving, M; Alves, EPurpose: To synthesize the body of knowledge on the factors influencing the QoL of mothers and fathers of preterm infants. Methods: A scoping review was performed. Publications indexed in PubMed®, Web of Science™, CINAHL® and PsycINFO® were searched, targeting studies presenting original empirical data that examined parental perception on QoL after a preterm delivery. Eligibility and data extraction were conduc...