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A case study of polypharmacy management in nine European countries: Implication...

McIntosh, Jennifer; Alonso, Albert; MacLure, Katie; Stewart, Derek; Kempen, Thomas; Mair, Alpana; Castel-Branco, Margarida; Codina, Charles

Background Multimorbidity and its associated polypharmacy contribute to an increase in adverse drug events, hospitalizations, and healthcare spending. This study aimed to address: what exists regarding polypharmacy management in the European Union (EU); why programs were, or were not, developed; and, how identified initiatives were developed, implemented, and sustained. Methods Change management principles (Kot...


Polypharmacy Management by 2030: a patient safety challenge

Mair, Alpana; Fernandez-Llimos, Fernando; Alonso, Albert; Harrison, Cathy; Hurding, Simon; Kempen, Thomas; Kinnear, Moira; Michael, Nils

Executive Summary Inappropriate polypharmacy and medicines adherence in the elderly is one of the most significant public health challenges of the current age. This burden is set to increase as the population ages and more people suffer from multiple long term conditions. There remains a lack of evidence-based solutions, as both medical research and healthcare delivery models have focused on single disease inte...


A modified Delphi study to determine the level of consensus across the European...

Stewart, Derek; Gibson-Smith, Kathrine; MacLure, Katie; Mair, Alpana; Alonso, Albert; Codina, Carles; Cittadini, Antonio; Fernandez-Llimos, Fernando

Background Inappropriate use of multiple medicines (inappropriate polypharmacy) is a major challenge in older people with consequences of increased prevalence and severity of adverse drug reactions and interactions, and reduced medicines adherence. The aim of this study was to determine the levels of consensus amongst key stakeholders in the European Union (EU) in relation to aspects of the management of polyph...


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