4 documents found, page 1 of 1
Dissecting the role of microRNAs in effector versus regulatory CD4+ T cell diff...
Cunha, Carolina; Romero, Paula Vargas; Inácio, Daniel; Pais, Ana Teresa; Pelicano, Catarina; Sobral, Daniel; Costa, Marina; Mensurado, SofiaIntroduction: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They have been implicated in the regulation of the differentiation and function of CD4+ T cell subsets, key players in host defense against pathogens, but also responsible for immune-mediated diseases depending on the correct vs incorrect balance, respectively, between pro-infla...
microRNA-122 and microRNA-1247 regulate the pathogenic phenotype of effector CD...
Cunha, Carolina; Romero, Paula Vargas; Pelicano, Catarina; Pais, Ana Teresa; Inácio, Daniel; Papotto, Pedro; Sobral, Daniel; Amado, TiagoAutoimmune diseases are often associated with an imbalance between CD4+ T cell subsets, namely pro-inflammatory effector cells, including T helper 1 (Th)1 and Th17 cells (IFN-γ- and IL-17-producers, respectively), and anti-inflammatory Foxp3+ regulatory cells (Treg). The differentiation of these distinct CD4+ T cell subsets is known to be regulated by microRNAs (miRNAs), small non-coding RNAs that fine-tune gen...
Dissecting the role of microRNAs in effector versus regulatory CD4+ T cell diff...
Cunha, Carolina; Romero, Paula Vargas; Pelicano, Catarina; Pais, Ana Teresa; Inácio, Daniel; Papotto, Pedro; Amado, Tiago; Gomes, Anita Q.CD4+ T cells are key players in host defense against pathogens, but an incorrect balance between CD4+ T cell subsets, namely pro-inflammatory effector cells, including T helper 1 (Th)1 and Th17 cells (IFN-γ- and IL-17-producers, respectively), and anti-inflammatory regulatory cells (Treg; Foxp3+ subset), can lead to immune-mediated diseases. MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate ...
MicroRNA determinants of the balance between effector and regulatory CD4+ T cel...
Cunha, Carolina; Romero, Paula; Pelicano, Catarina; Papotto, Pedro; Amado, Tiago; Inácio, Daniel; Gomes, Anita Quintal; Silva-Santos, BrunoMicroRNAs (miRNAs) are highly conserved small non-coding RNAs that control gene expression at the post-transcriptional level. As in many physiological processes, they have been implicated in the regulation of the immune system, including the differentiation and function of CD4+ T cell subsets. CD4+ T cells are key players in host defense against pathogens, but an incorrect balance between different CD4+ T cell ...