Coronavirus (COVID-19) disease outbreak caused a worldwide pandemic with a powerful lethal potential and still, there is no specific treatment to it. Natural bioactive molecules like curcumins were investigated in this work aiming to block the active site of COVID-19 Main protease (Mpro), since they present several biological activities, being more suitable in terms of fewer side effects, once this disease over...
Pesticides are products intended for the production sector, whose purpose is to preserve ecosystems by altering the composition of flora or fauna in order to preserve them from the harmful action of living beings considered harmful. The insertion of pesticides in Brazil is due to the Green Revolution, the mechanization and the intense use of agricultural inputs. As a result, damage to workers' health and the en...
Experience is an essential element for meaningful learning, although teacher formation does not always pay due attention to the elements that underlie this human aspect. The study presented in this text analyzes the discourses of the 20 students of the Degree in Biological Sciences who completed the discipline Fundamentals of Philosophy of Sciences at the State University of Ceará, UECE, Iguatu campus, in the y...
Objective: The objective of this study was to use the molecular fractionation with conjugate caps (MFCC) method to elucidate the possible interaction mechanism of anacardic acid (AA) with the saturated alkyl chain (AA0) in the Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase (TcGAPHD) enzyme. Methods: Initially, the geometry optimization of the AA three-dimensional structure (with the pentadecyl chain...