Herein we report that crotamine, a small lysine- and cysteine-rich protein from the venom of the South American rattlesnake, can rapidly penetrate into different cell types and mouse blastocysts in vitro. In vivo, crotamine strongly labels cells from mouse bone marrow and spleen and from peritoneal liquid, as shown by fluorescent confocal laser-scanning microscopy. Nuclear localization of crotamine was observed...
Crotamine, one of the main toxic components of Crotalus durissus terrificus venom, is a small non-enzymatic basic polypeptide, which causes hind limb paralysis and necrosis of muscle cells. It is well-known that several toxins penetrate into the cytosol through endocytosis, although in many cases the mechanism by which this occurs has not been fully investigated. Recently, using low concentrations of crotamine,...
Made available in DSpace on 2013-08-28T14:12:40Z (GMT). No. of bitstreams: 1 WOS000305892100123.pdf: 1025211 bytes, checksum: f3114ad3d761d448ea4009979a8c8d68 (MD5); Made available in DSpace on 2013-09-30T18:31:32Z (GMT). No. of bitstreams: 2 WOS000305892100123.pdf: 1025211 bytes, checksum: f3114ad3d761d448ea4009979a8c8d68 (MD5) WOS000305892100123.pdf.txt: 56945 bytes, checksum: e71c3f4e9d87411582be429d4ea1669f...