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Transitioning intravenous epoprostenol to oral selexipag in idiopathic pulmonar...

Alexandre, André; Furtado, Inês; Gonçalves, Fabienne; Gonçalves, Fabienne; Melo, Alzira; Alves, Joana; Santos, Mario; Reis, Abilio

Intravenous (i.v.) prostacyclin is the cornerstone treatment in high-risk pulmonary arterial hypertension (PAH) patients. Selexipag is an orally available prostacyclin receptor agonist. Limited data are available regarding the feasibility of transitioning from i.v. epoprostenol to selexipag. A 50-year-old woman with idiopathic PAH was diagnosed in a World Health Organization (WHO) Functional Class (FC) IV. She ...


Are Outcomes of Non-Invasive Ventilation in Acute Respiratory Failure Similar i...

Costa, Ana Rita; Furtado, Inês; Gonçalves, João; Meireles, Mariana; Neves, João; Mateus, Andrea

Introduction: Acute respiratory failure (ARF) is one of the most prevalent causes of observation in the emergency department in an ageing population. Non-invasive positive pressure ventilation (NIPPV) has shown good results in critically ill with ARF. The evidence of NIPPV outcomes in old patients is scarce. The aim of our study is to analyse outcomes of NIPPV use in this population. Methods: We conducted a pro...


Different disease, same challenges: Social determinants of tuberculosis and COV...

Duarte, R.; Aguiar, A.; Pinto, M.; Furtado, Inês; Tiberi, S.; Lönnroth, K.; Migliori, G.B.

Infectious diseases, such as tuberculosis (TB) and the novel coronavirus (COVID-19) relate to environmental factors, understanding of which is essential to inform policy and practice and tackle them effectively. The review follows the conceptual framework offered by the World Health Organization Commission on Social Determinants of Health (defined as "all those material, psychological and behavioural circumstan...


Disability and its clinical correlates in pulmonary hypertension measured throu...

Reis, Abílio; Santos, Mario; Furtado, Inês; Cruz, Célia; Sá-couto, Pedro; Queirós, Alexandra; Almeida, Luis; Rocha, Nelson

Objective: To characterise the degree of disability in pulmonary hypertension (PH) patients based on the World Health Organisation Disability Assessment Schedule 2.0 (WHODAS 2.0). Method: A prospective and observational study of patients with documented PH (N = 46). Patients completed the WHODAS 2.0 questionnaire during a scheduled routine clinical visit, and their demographic and clinical characteristics were ...


Disability and its clinical correlates in pulmonary hypertension measured throu...

Reis, Abílio; Santos, Mário; Furtado, Inês; Cruz, Célia; Sá-Couto, Pedro; Queirós, Alexandra; Almeida, Luís; Rocha, Nelson

Objective: To characterise the degree of disability in pulmonary hypertension (PH) patients based on the World Health Organisation Disability Assessment Schedule 2.0 (WHODAS 2.0). Method: A prospective and observational study of patients with documented PH (N = 46). Patients completed the WHODAS 2.0 questionnaire during a scheduled routine clinical visit, and their demographic and clinical characteristics were ...


Health-related quality of life in pulmonary hypertension and its clinical corre...

Reis, Abílio; Santos, Mário; Vicente, Margarida; Furtado, Inês; Cruz, Célia; Melo, Alzira; Carvalho, Luísa; Gonçalves, Fabienne; Almeida, Luís

Background: Health-related quality of life (HRQoL) impairment is common in pulmonary hypertension (PH), but its clinical predictors are not well established. This study aims to characterize the HRQoL of patients with pulmonary arterial hypertension (PAH) and other precapillary forms of PH (pcPH) and to explore its clinical correlates. Materials and Methods: A cross-sectional, observational study of patients wit...


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