3 documents found, page 1 of 1
Estudo da interação com DNA, citoxicidade e da atividade das topoisomerases I e...
Soares, Bruno MarquesBufadienolides show a wide variety of biological activities, including antineoplastic activities. The present study evaluated the cytotoxic potential and mechanisms of action of two bufadienolides: bufalin (BUF-05) and 3-acetate bufalin (BUF-06). Cytotoxic potential was evaluated using seven human tumor cell lines, three normal murine cell lines and human peripheral blood mononuclear cells (PBMC). Both bufadien...
Evaluation of the cytotoxicity of structurally correlated p-menthane derivatives
Andrade, Luciana Nalone; Lima, Tamires Cardoso; Amaral, Ricardo Guimarães; Pessoa, Cláudia do Ó; Moraes Filho, Manoel Odorico de; Soares, Bruno MarquesCompounds isolated from essential oils play an important role in the prevention and treatment of cancer. Monoterpenes are natural products, and the principal constituents of many essential oils. The aim of this study was to investigate the cytotoxic potential of p-menthane derivatives. Additionally, analogues of perillyl alcohol, a monoterpene with known anticancer activity, were evaluated to identify the molec...
Hellebrigenina, um bufodienolídeo com potencial ação compatível de inibidor cat...
Soares, Bruno MarquesBufodienolides are cardioactive steroids of 24 carbons, originally isolated from a frog’s skin extract of the family Bufonidae used in Chinese medicine. Bufodienolides shows many biological activities, including anticancer activities. Related to antitumor activity, the bufodienolídeos has been shown to inhibit the growth of several human cancer cell lines by inducing apoptosis and cell cycle arrest. This study ...