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Tumour ADC measurements in rectal cancer: effect of ROI methods on ADC values a...

Lambregts, DM; Beets, GL; Maas, M; Curvo-Semedo, L; Kessels, AG; Thywissen, T; Beets-Tan, RG

OBJECTIVES: To assess the influence of region of interest (ROI) size and positioning on tumour ADC measurements and interobserver variability in patients with locally advanced rectal cancer (LARC). METHODS: Forty-six LARC patients were retrospectively included. Patients underwent MRI including DWI (b0,500,1000) before and 6-8 weeks after chemoradiation (CRT). Two readers measured mean tumour ADCs (pre- and post...


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