4 documents found, page 1 of 1
Bacteriophages a bio sustainable solution to tackle Alzheimer´s disease
Lima, Alexandre; de Graaff, Wim; Cristóvão, Joana S.; Brosens, Niek; Aronica, Eleonora; Gomes, Cláudio M.; Azeredo, Joana; Kessels, HelmutIntroduction: Amyloid-beta (AB) is a prime suspect to cause Alzheimers disease (AD), an irreversible, progressive and age-dependent neurodegenerative disorder affecting millions of people worldwide. An accumulation of AB in the brain leads to its aggregation into soluble oligomeric and fibrillar clusters, which are the culprits to impair synaptic function and memory formation in mice models. Currently, we lack ...
A phage-based platform to detect amyloid-beta oligomers
Lima, Alexandre; de Graaff, Wim; Aronica, Eleonora; Martins, Ivone M.; Azeredo, Joana; Kessels, HelmutAmyloid-beta (A) is a prime suspect to cause Alzheimers disease (AD). A peptides can aggregate into soluble oligomers and fibrils, to finally deposit in insoluble plaques. Even though the plaques are main hallmarks of Alzheimers, before plaque formation, the still-soluble A oligomers and fibrils are the culprits that trigger a loss in synapses and memory dysfunction. However, whereas we are well-able to identif...
Engineered M13-bacteriophages to target amyloid- peptide in oligomeric/fibrilla...
Martins, Ivone M.; Silva, Ana Isabel M.; Azeredo, Joana; Kessels, Helmut[Excerpt] Alzheimer´s Disease (AD) is an age-dependent neurodegenerative disease with very high incidence worldwide and detrimental consequences. Manifests as a decline in cognitive functions and memory loss, characterized at molecular level by an increased deposition of amyloid-beta (AB) plaques. Nevertheless, it is AB in the still-soluble oligomeric/fibrillar form that impairs synaptic function and memory enc...
Phage display technology - Potential and Applications
Martins, Ivone M.; Nóbrega, Franklin L.; Ferreira, Débora; Silva, A.; Azevedo, H. S.; Reis, R. L.; Kessels, Helmut; Rodrigues, L. R.; Azeredo, Joana