Made available in DSpace on 2018-11-26T16:48:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-08-01; Fundacao de Amparo a Pesquisa do Estado de Mato Grosso; Compared with the extensor digitorum longus (EDL) muscle of control rats (C), the EDL muscle of rats fed a low-protein, high-carbohydrate diet (LPHC) showed a 36% reduction in mass. Muscle mass is determined by the balance between protein synthesis...
Proteasomes are multi-subunit proteases involved in several mechanisms and thought to contribute to the regulation of cellular homeostasis. Here, we report for the Wrst time biochemical evidence for the existence of a ubiquitin–proteasome proteolytic pathway in this parasite. Proteasomes from both cercariae and adult worms exhibited a high preference for hydrolysis of the substrate Suc- LLVY-AMC, although in th...