17 documents found, page 1 of 2
Suturable elastomeric tubular grafts with patterned porosity for rapid vascular...
Bellani, Caroline Faria; Yue, Kan; Flaig, Florence; Hébraud, Anne; Ray, Pengfei; Annabi, Nasim; Selistre De Araújo, Heloísa SobreiroMade available in DSpace on 2021-06-25T10:59:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01; Vascularization is considered to be one of the key challenges in engineering functional 3D tissues. Engineering suturable vascular grafts containing pores with diameter of several tens of microns in tissue engineered constructs may provide an instantaneous blood perfusion through the grafts improving ce...
Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratin...
Barros, Natan R [UNESP]; Kim, Han-Jun; Gouidie, Marcus J; Lee, KangJu; Bandaru, Praveen; Banton, Ethan A; Sarikhani, Einollah; Sun, WujinMade available in DSpace on 2021-06-25T10:22:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01; The skin serves a substantial number of physiological purposes and is exposed to numerous biological and chemical agents owing to its large surface area and accessibility. Yet, current skin models are limited in emulating the multifaceted functions of skin tissues due to a lack of effort on the optimiza...
Self-assembled hydrogel fiber bundles from oppositely charged polyelectrolytes ...
Sant, Shilpa; Coutinho, Daniela F.; Gaharwar, Akhilesh K.; Neves, N. M.; Reis, R. L.; Gomes, Manuela E.; Khademhosseini, AliFiber bundles are present in many tissues throughout the body. In most cases, collagen subunits spontaneously self-assemble into a fibrilar structure that provides ductility to bone and constitutes the basis of muscle contraction. Translating these natural architectural features into a biomimetic scaffold still remains a great challenge. Here, a simple strategy is proposed to engineer biomimetic fiber bundles t...
Google Glass-Directed Monitoring and Control of Microfluidic Biosensors and Act...
Zhang, Yu Shrike; Busignani, Fabio; Ribas, João; Aleman, Julio; Rodrigues, Talles Nascimento; Shaegh, Seyed Ali Mousavi; Massa, SolangeGoogle Glass is a recently designed wearable device capable of displaying information in a smartphone-like hands-free format by wireless communication. The Glass also provides convenient control over remote devices, primarily enabled by voice recognition commands. These unique features of the Google Glass make it useful for medical and biomedical applications where hands-free experiences are strongly preferred....
Hydrophobic hydrogels: towards construction of floating (Bio) microdevices
Oliveira, N. M.; Yu Shrike Zhang; Jie Ju; Ai-Zheng Chen; Yu Chen; Sonkusale, Sameer R.; Dokmeci, Mehmet Remzi; Reis, R. L.; Mano, J. F.Hydrogels, formed through crosslinking of hydrophilic polymer chains, represent a class of materials that are capable of holding large volumes of water. Here we report a novel class of hydrophobic hydrogels that can free-float on the surface of different aqueous media by coating conventional hydrogels with a layer of hydrophobic microparticles. We further demonstrate that these floating hydrogel-based devices c...
A textile platform using mechanically reinforced hydrogel fibres towards engine...
Costa-Almeida, R.; Tamayol, A.; Yazdi, I. K.; Avci, H.; Fallahi, A.; Annabi, N.; Reis, R. L.; Gomes, Manuela E.; Khademhosseini, AliINTRODUCTION: Tendon injuries can result from tendon overuse or trauma, resulting in substantial pain and disability. Given that natural or surgical repair of tendons lead to a poor outcome in terms of mechanical properties and functionality, there is a great need for tissue engineering strategies. Textile platforms enable the generation of biomimetic constructs [1]. Therefore, the main goal of this study is th...
Antifungal nanofibers made by controlled release of sea animal derived peptide
Viana, Juliane F. C.; Carrijo, Jéssica; Freitas, Camila G.; Paul, Arghya; Alcaraz, Jarib; Lacorte, Cristiano C.; Migliolo, Ludovico; Andrade, César A.Candida albicans is a common human-pathogenic fungal species with the ability to cause several diseases including surface infections. Despite the clear difficulties of Candida control, antimicrobial peptides (AMPs) have emerged as an alternative strategy for fungal control. In this report, different concentrations of antifungal Cm-p1 (Cencritchis muricatus peptide 1) were electrospun into nanofibers for drug de...
The osteogenic differentiation of SSEA-4 sub-population of human adipose derive...
Mihaila, Silvia M.; Gaharwar, Akhilesh K.; Reis, R. L.; Khademhosseini, Ali; Marques, A. P.; Gomes, Manuela E.How to surpass invitro stem cell differentiation, reducing cell manipulation, and lead the in situ regeneration process after transplantation, remains to be unraveled in bone tissue engineering (bTE). Recently, we showed that the combination of human bone marrow stromal cells with bioactive silicate nanoplatelets (sNPs) promotes the osteogenic differentiation without the use of standard osteogenic inductors. Ev...
Amphiphilic beads as depots for sustained drug release integrated into fibrilla...
Gaharwar, Akhilesh K.; Mihaila, Silvia M.; Kulkarni, A. A.; Patel, A.; Luca, A. Di; Reis, R. L.; Gomes, Manuela E.; Blitterswijk, C. A. van; Moroni, L.Native extracellular matrix (ECM) is a complex fibrous structure loaded with bioactive cues that affects the surrounding cells. A promising strategy to mimicking native tissue architecture for tissue engineering applications is to engineer fibrous scaffolds using electrospinning. By loading appropriate bioactive cues within these fibrous scaffolds, various cellular functions such as cell adhesion, proliferation...
Photocrosslinkable Kappa-carrageenan hydrogels for tissue engineering applications
Mihaila, Silvia M.; Gaharwar, Akhilesh K.; Reis, R. L.; Marques, A. P.; Gomes, Manuela E.; Khademhosseini, AliKappa carrageenan ( κ -CA) is a natural-origin polymer that closely mimics the glycosaminoglycan structure, one of the most important constituents of native tissues extracellular matrix. Previously, it has been shown that κ -CA can crosslink via ionic interactions rendering strong, but brittle hydrogels. In this study, we introduce photocrosslinkable methacrylate moieties on the κ -CA backbone to create physica...